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23 Cards in this Set
- Front
- Back
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what is the biologic pathway to the production of RBC
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pluripotent stem cells, myeloid stem cells, RBC
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TRT for GIII- GIV cancer induced anemai
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blood transfusions
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TRT for GI- GII cancer induced anemai
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Epotetin alfa or Darbopoetin
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Benefit of Darbopoetin alfa over Epoetin alfa
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longer acting Epotein
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Why is anemia so bad in cancer?
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increases the risk of life-threatening infections, hospitalization, IV antibiots
limits dose of many chemotherapy QOL decreased |
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prevention of neutropenic fever/ dose delay
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lower dose of chemo
Sargramostim (Leukine, GM-CSF) Filgrastim (Neupogen, G-CSF) Pegfilgrastim (Neulasta, pegG-CSF)Longer acting G-CSF |
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when are colony stimulating factors used
primary secondary |
primary- before 1st cycle when neutropenic fever risk exceeds 20%
secondary- after documented neutropenia for subsequent cycles or after high dose chemotherapy with BMT (bone marrow transplant) |
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don't use colony stimulating factors during
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chemotherapy
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which CSF targets early precursors to monocytes and granulocytes
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Sargramostim
Leukine GM- CSF (Berlex) |
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which CSF is derived from E. coli
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Filgramstim
Neupogen G- CSF |
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which CSF has NO pulmonary edema
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Filgramstim
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which CSF causes neutrophil demargination
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Filgramstim
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which CSF only does precursors to granulocytes
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Filgramstim
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T/F G/GM-CSF decrease the number of neutropenic days after chemo and increase survival
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F- G/GM-CSF DO decrease the number of neutropenic days after chemo BUT neither increase survival unless help maintain dose intensity necessary to cure a disease
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major SE of CSF
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bone pain and injection site pain
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thrombocytopenia is a platelet count _____
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less than 150,000/µL
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At what platlet count is spontaneous bleeding a concern
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less than 20,000/µL
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At what platlet count is bleeding secondary to traumatic injury a concern
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40,000 - 60,000/µL
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what things increase platlet destruction
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drug- induced, alloimmune, autoimmune, consumptive (TTP, HUS, DIC)
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what things decrease platlet production
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drugs, infection, nutritional defects, radiation
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when do you bring on the platlet tranfusion in an uncomplicated pt
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with a platelet count of less than 20,000/µL
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when do you bring on the platlet tranfusion in an active bleed
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platelet count of 30,000 - 50,000/µL
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when do you bring on the platlet tranfusion in a surgery pt
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platelet count less than 70,000/µL
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