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What is anatomy?

the study of the structures of the body and the relationships among and between those structures

(describe what you see and locate organs)

What is physiology?

the study of the functions of body structures

(are organs/structures working properly)

Gross anatomy is also called:

macroscopic anatomy

What is gross anatomy?

a type of anatomy that can be undertaken without a microscope

What is microscopic anatomy?

requires a microscope (e.g., light or phase microscope)

micro = 10 to the -6
nano = 10 to the -9

What is ultramicroscopic anatomy?

requires the use of an electron microscope, either:
T.E.M. - transmission electron microscopy (in-depth, inside), or
S.E.M. - scanning electron microscopy (surface)

magnification of 250,000X

What is regional anatomy?

studies specific regions of the body

(e.g., head and neck, thoracic)

Microscopic anatomy is also equal to:

histology (and cytology)

What is systemic anatomy?

the study of a specific system

(e.g., digestive system, endocrine system)

What is radiographic anatomy?

study of the structure of the body using X-rays

What is cytology?

microscopic study of the individual cells

What is histology?

microscopic study of the tissues (groups of cells)

What is embryological anatomy?

study of prenatal development (the fertilized egg) from days 12-58 (thereafter it is a fetus)

What are some non-invasive imaging techniques?

MRI
CAT Scan
PET Scan
X-ray

What is pathological anatomy?

study of structural change associated with disease (or death)

What is systemic physiology?

study of the function of the systems

(e.g., the study of how you breathe using the respiratory system)

What is cell physiology?

the study of the function of a cell, how it moves and does its work

What is neurophysiology?

the study of the function of nerve cells (reflexes, etc.)

What is endocrinology?

the study of hormones and how they control body functions

What is immunology?

the study of the body defense mechanisms (antibodies/immunoglobulin) against antigens

What is homeostasis?

an inner stability of the body, even if the environment outside of the body changes

homeo =
stasis=

same
standing

(everything in balance)

When is homeostasis achieved?

when structures (anatomy) and functions (physiology) are properly coordinated

What makes the entire regulation process of homeostasis possible?

the coordinated action of many organs and tissues under the control of the:

- nervous system and
- endocrine system

What happens when homeostasis breaks down?

we get sick or die

What is one way to disrupt homeostasis?

introduce stress

(a stressor/stimulus/disruptor)

What factors interrupt homeostasis and provoke change in the body?

stressors
stimuli
disruptors
(all mean the same)

Stress is the overall disruption that forces the body to:

make adaptive changes

Factors causing stress are called:

stressors

(or stimuli, or disruptors)

What are some stressors/stimuli/disruptors?

- heat/cold
- viruses
- mental disturbances
- hormones

What does the feedback system look like?

receptor---> control center ----> effector

Name some receptors.

thermoreceptors
chemoreceptors
nociceptors

Which is the "stupid animal brain"?

the hypothalamus

Which portion of the brain is responsible for higher-level/more rational thought?

the cortex

The feedback system is:

a response to the initiating stimulus

Feedback may be:

positive or negative

What is negative feedback?

when the response is opposite to the initiating stimulus

(e.g., body increases production of heat to oppose cold weather)

What is positive feedback?

when the response reinforces the initial stimulus

positive feedback leads to death except in special cases like childbirth, lactation, and blood clotting

List the organizational levels of the body.

- atom
- element
- molecule/compound
- cells
- tissues
- organs
- organ systems
- organism

What are the levels of organization found in both living and nonliving things?

- atoms
- elements
- molecules/compounds

What is the basic unit of all matter?

atom

What are the smallest thing we are made of?

atoms

What is a molecule?

a combination of 2 or more atoms

(e.g., O2, H2)

What is a compound?

a molecule containing atoms of more than one element

(e.g., H2O, CO2, protein, lipid)

What levels of organization are only found in living things?

- cells
- tissues
- organs
- organ systems
- (organism)

What are cells?

the smallest independent units of life

the smallest living thing we're made of

What are tissues?

a group of similar cells that perform a specific function

How many types of tissue are there? What are they?

4
- nervous
- epithelial
- muscular
- connective

Where is epithelial tissue located?

in the skin and lining of organs

What functions does epithelial tissue perform?

- protection
- transport
- secretion
- excretion
- absorption

Where is connective tissue located?

throughout the body
in many organs

What functions does connective tissue perform?

- support
- protection (e.g., bone)
- repair

Name some connective tissues.

- tendons
- ligaments
- cartilage
- fat
- blood
- bone

What are the three types of muscle tissue?

- skeletal
- smooth
- cardiac

What are the two types of involuntary muscle tissues?

- smooth
- cardiac

Which type of muscle is voluntary?

skeletal

Where is skeletal muscle found?

in the limbs, face, abdomen, etc.

Where is smooth muscle found?

in the digestive system (peristalsis), blood vessels, uterus, etc.

Where is cardiac muscle found?

in the heart

Where is nerve tissue found?

- brain
- spinal cord
- nerves

What is the function of nerve tissue?

- respond to stimuli
- transport nerve impulses from one part of the body to another

What is an organ?

two or more kinds of tissue bound together to form a structure

What is the largest organ of the body?

skin

What is a system?

a group of organs and their tissues that work together to perform a major function

What comprises the integumentary system?

- skin
- nails
- hair
- sweat glands
- oil glands

What is the function of the integumentary system?

- protection
- regulation of body temperature
- sensory reception

What comprises the skeletal system?

- bone
- cartilage

What is the function of the skeletal system?

- support the body
- protect organs
- manufacture RBCs
- provide lever mechanism for movement

What comprises the muscular system?

- skeletal muscle
- smooth muscle
- cardiac muscle

What is the function of the muscular system?

- body movement
- produce body heat

What comprises the nervous system?

- brain
- spinal cord
- peripheral nerves
- sensory organs

What is the function of the nervous system?

- regulates body activities
- initiates action of muscles
- promotes homeostasis

What comprises the endocrine system?

ductless glands

What is the function of the endocrine system?

- secrete hormones
- promotes homeostasis

What comprises the cardiovascular system?

- heart
- blood vessels
- blood

What is the function of the cardiovascular system?

pump blood through the vessels for:
- transportation of gases
- movement of nutrients

What comprises the respiratory system?

- lungs
- airways
- nose
- pharynx
- larynx

What is the function of the respiratory system?

- breathing
- exchange of gases between air and blood

What comprises the digestive system?

- organs from mouth to anus
- accessory structures such as liver, pancreas, etc.

What is the function of the digestive system?

- break down food
- remove solid waste

What comprises the urinary system?

- kidneys
- ureters
- bladder
- urethra

What is the function of the urinary system?

- eliminate metabolic wastes
- regulate blood pressure
- regulate water-salt balance

What comprises the reproductive system?

- ovaries
- testes
- germ cells
- accessory glands
- ducts

What is the function of the reproductive system?

continuation of the species

What comprises the lymphatic system?

- lymph nodes
- lymph vessels
- tonsils

What is the function of the lymphatic system?

- immune system defense of body
- fat transport

What comprises the immune system?

lymphocytes (T and B cells)

What is the function of the immune system?

- to defend the body from foreign invaders
- assist in repair of trauma

What is an organism?

the complete human (animal)
the highest level of organization

From where did "anatomical position" originate?

Vienna, Austria

Describe anatomical position.

- body standing erect
- facing forward
- feet together
- arms hanging at sides
- palms facing forward (the way the body is facing)

Divides the body symmetrically into left and right halves

(longitudinal or vertical)

midsagittal or median plane

Divides the body asymmetrically into left and right parts

(longitudinal or vertical)

sagittal or parasagittal plane

Divides the body into anterior and posterior sections

(longitudinal or vertical)

frontal or coronal plane

Divides the body horizontally into superior and inferior sections

transverse or horizontal plane

or crossection(al)

cranial or cephalic

toward the head

Caudal

toward the tail

superior

above

to move up on a human

inferior

below

to move down on a human

anterior or ventral

toward the front

posterior or dorsal

toward the back

medial

toward the midline

lateral

away from the midline

proximal

nearer to the trunk

(only for limbs)

distal

further from the trunk

(only for limbs)

superficial or external

near the surface

deep or internal

farther from the surface

dorsal of foot

upper surface of foot

dorsal of hand

back of hand

parietal

related to body walls

(e.g., pleural membrane is parietal to lung)

visceral

related to interior organ

(e.g., lung is visceral to pleural membrane)

supine

to recline on one's back

prone

to recline on one's front
(lie face down on stomach)

oblique

at an angle

What are the two main regions of the body?

- axial part
- appendicular part

What comprises the axial part of the body?

- head
- neck
- thorax
- abdomen
(basically everything but arms and legs)

(I saw shoulder and pelvic girdles included with appendicular at one point????)

What comprises the appendicular part of the body?

- upper limbs
- lower limbs

What is the purpose of the body cavities?

to house and protect the organs

What are the two main body cavities?

- ventral
- dorsal

(cavities are all in axial part b/c appendicular part--arms and legs--is solid)

What comprises the dorsal (posterior) cavity?

- cranial cavity
- spinal (vertebral) cavity

What is the composition and function of the cranial cavity?

- formed by the cranial bones
- houses and protects the brain

What is the composition and function of the vertebral (spinal) cavity?

- formed by vertebrae of backbone
- houses and protects spinal cord and roots of spinal nerves

What cavities comprise the ventral (anterior) cavity?

- thoracic cavity (upper)
- abdominopelvic cavity (lower)

Ventral (anterior) body cavity is located in the ____ _____ of the body.

front aspect

What comprises the thoracic cavity?

- pericardial cavity
- pleural cavity
- mediastinum

What is contained in the pericardial cavity?

the heart

What lines the pericardial cavity?

the pericardium

What type of membrane is the pericardium?

serous

What is contained in the (right and left) pleural cavities?

the lungs

What lines the pleural cavities?

the pleura

What type of membrane is the pleura?

a serous membrane

What is the mediastinum?

the region or space between the lungs, the thoracic inlet, and the diaphragm

What is contained within the mediastinum?

- esophagus
- trachea
- primary bronchi
- thymus gland
- heart (pericardial cavity)
- large blood vessels
- lymphatic vessels

What lines the abdominopelvic cavity?

the peritoneum

What type of membrane is the peritoneum?

serous

What are the boundaries for the abdominal cavity?

- diaphragm at the top
- pelvic brim at the bottom

What is contained within the abdominal cavity?

- stomach
- spleen
- pancreas
- liver
- gallbladder
- most of small and large intestines
- kidneys
- adrenal glands
- most of ureters
- major blood vessels (inferior vena cava, abdominal aorta)

What are the boundaries for the pelvic cavity?

- pelvic brim at the top
- bottom of the cavity

What is contained within the pelvic cavity?

- urinary bladder
- parts of small and large intestine
- remainder of ureters
- vermiform appendix
- internal reproductive organs of male (seminal vesicles, prostate) and female (ovaries, fallopian tubes, uterus, cervix, upper vagina)

Into how many quadrants can the abdominopelvic cavity be divided? Name them.

4
- right upper quadrant
- right lower quadrant
- left upper quadrant
- left lower quadrant

Who uses quadrants in their jobs?

clinicians, surgeons, etc.

Into how many regions can the abdominopelvic cavity be divided? Name them.

9
- right and left hypochondriac
- right and left lumbar
- right and left iliac/inguinal
- epigastric
- umbilical
- hypogastric

Axillary

armpit

Buccal

cheek

Carpal

wrist

Celiac

abdomen

Cervical

neck

Costal

ribs

Gluteal

buttocks

Loin

lumbar (lower back between ribs and pelvis)

Palmar (metacarpal)

palm of hand

Pectoral

chest

Pedal (pedis)

foot

Perineal

region between anus and external reproductive organs

Plantar

sole of foot

Popliteal

back of knee

Cephalic (cranial) (caput)

head

Brachial

arm

Antecubital

front of elbow

Antebrachial

forearm

Crural

leg

Tarsal

ankle/instep

Inguinal

groin

Coxal

hip

Umbilical

navel

Mental

chin

Acromial

shoulder (point of)

Sural

calf

Calcaneal

heel of foot

Peritoneum

lining of abdominal cavity

What are 7 characteristics of living forms/living cells?

- metabolism
- responsiveness
- differentiation
- growth
- reproduction
- adaptation
- movement

MR D GRAM

What is metabolism?

sum of all chemical processes that keep our bodies alive and healthy

What are the 2 phases/parts of metabolism?

- anabolism
- catabolism

What is catabolism?

phase of metabolism that provides energy by breaking down complex molecules into simple molecules

(e.g., proteins ---> amino acids)

What is anabolism?

phase of metabolism that uses the energy from catabolism to build up body's structural and functional components

a.k.a. biosynthesis

(e.g., amino acids ---> proteins)

What is another word for anabolism?

biosynthesis

What is responsiveness, with respect to characteristics of living forms/cells?

to respond to changes

to give a response to a stimulus

What is movement, with respect to characteristics of living forms/cells?

motion of the body, organs, or cells

What is growth, with respect to characteristics of living forms/cells?

increase in size and complexity

What is differentiation, with respect to characteristics of living forms/cells?

specialization of the cells

(at conception all cells look alike, then differentiate==stem cells)

What is reproduction, with respect to characteristics of living forms/cells?

formation of new cells or formation of a new individual

What is adaptation, with respect to characteristics of living forms/cells?

ability to adjust to any given condition

Who uses abdominopelvic regions in their work?

anatomists

Whenever one is describing a body structure and establishes the relationship of that structure with the neighboring structure, it means that he is studying:

a. physiology
b. endocrinology
c. anatomy
d. cytology

c. anatomy

The big toe is ______ to the other toes of the same side

medial

The stomach is _____ to the spleen

medial

The kidneys are _______ to the vertebral column

lateral

The skull is _______ to the brain

superficial

The head is ______ to the thorax

superior

Your arm is _______ to the wrist

proximal

Your legs are _______ to your thighs

distal

In anatomical position your palms are facing _______.

anteriorly

The breasts are _______ to the navel

lateral

The lungs are ______ to the ribs

deep

The skin is _______ to the muscle

superficial

Your eyes are ________ to your nose

lateral

Your thumb is ______ to the pinky.

lateral

The radius is ______ to the ulna

lateral

The sternum is ventral to the vertebral column. (T/F)

true

The vertebral column is posterior to the sternum. (T/F)

true

Visceral and parietal have the same meaning. (T/F)

false

Caudal and cranial are opposite, likewise plantar and dorsal are also opposite. (T/F)

true

The amplification of the effect of a stimulus will result in a “negative feedback”. (T/F)

false

The enhancement of the action of a stimulus will definitely be classified as a “positive feedback”. (T/F)

true

Homeostasis is mainly achieved through “negative feedback”. (T/F)

true

During surgery, the surgeon does his best to ensure that the patient does not bleed heavily through a process called hemostasis. Is it a positive feedback or a negative feedback?

negative feedback

In case that the surgeon perform hemostasis, the feedback is negative because it is against the stimulus. In case hemostasis occurs spontaneously without outside intervention then the feedback is positive.

In which cavities are these organs located? Be very specific.

ovaries
heart
lungs
transverse colon

pelvic cavity
thoracic cavity/pericardial cavity
thoracic cavity/pleural cavities
abdominal cavity

In which cavities are these organs located? Be very specific.

abdominal aorta
urinary bladder
pancreas
thymus

abdominal cavity
pelvic cavity
abdominal cavity
thoracic cavity (mediastinum)

In which cavities are these organs located? Be very specific.

gall bladder
rectum
spine
primary bronchus
superior vena cava

abdominal cavity
pelvic cavity
vertebral/spinal cavity
thoracic cavity (mediastinum)
thoracic cavity

The head, the neck and the trunk are part of the appendicular region. (T/F)

false

The axial region encompasses

everything but the arms and legs

Is it true that cardiac muscle and skeletal muscles are both voluntary? Justify your answer.

No. Skeletal muscles are voluntary and move when you tell them. Cardiac (and smooth) muscles are involuntary. You do not tell your heart to beat or digestive system to conduct peristalsis.

Why do you think that smooth muscle can also be called visceral muscle?

Because the smooth muscle lines many of the organs (viscera), like the ones in the digestive tract responsible for moving food via peristalsis.

The type of tissue which responds readily to a stimulus is:

a. epithelial tissue
b. nervous tissue

b. nervous tissue

All these organs are part of respiratory system except:

nose, pharynx, larynx, trachea, sebaceous glands, bronchi, bronchioles, lungs

sebaceous glands

A collection of organs which work together to perform a specific function is called:

an organ system

Prenatal development is also called:

embryological anatomy

Laparoscopy and arthroscopy are non-invasive techniques. (T/F)

false

they are minimally invasive, but you're still cutting into someone

The ______ system dumps all its products into the bloodstream.

endocrine

The study of the bodily function is histology. (T/F)

false

physiology

These two systems, namely _____ and _____ are involved in regulating homeostasis.

nervous

endocrine

The lactation process is a negative feedback process. (T/F) Please justify your answer.

false

the more the baby eats, the more milk is made

The planes which divide the body symmetrically into left and right parts will be called:

median plane or

midsagittal plane

My stomach is located in the ______ plane.

parasagittal

The plane that divides the body into anterior and posterior is called:

frontal plane or

coronal plane

When an MRI is performed, the anatomical plane involved is:

transverse plane or

horizontal plane

The transverse plane is different from the horizontal plane. (T/F)

false

The sum of all the chemical reactions taking place in your body is called:

metabolism

Biosynthesis is considered the same as:

anabolic reaction
catabolic reaction

anabolic reaction

Specialization is also called _______ in anatomy.

differentiation

Decomposition is to catabolism what biosynthesis is to:

anabolism

The inguinal region is also called the:

iliac region

What is chemistry?

the study of the composition of matter

the study of what a structure is made of

What is matter?

anything that takes up space and has mass

Matter consists of:

chemical elements in pure form, and in combinations called compounds

In what three states does matter exist?

- solid
- liquid
- gas

What is mass?

the measure of the amount of matter an object contains

What is weight?

a measure of the pull of gravity on a mass

What is an element?

a substance that cannot be broken down into other substances by chemical means

a kind of atom

(hydrogen, oxygen, carbon, etc.)

How many naturally occurring elements are there?

92

How many naturally occurring elements are essential for life?

25

What four elements make up 96 percent of living matter?

- hydrogen (9.7%)
- oxygen (65%)
- nitrogen (3.2%)
- carbon (18.6%)

The remaining 4 percent of living matter is comprised of:

- potassium (K)
- sulfur (S)
- sodium (Na)
- chlorine (Cl)
- magnesium (Mg)
and trace elements

What is energy?

the ability to do work

The number of protons ______ an element and ______ _____ ______

defines

does not change

The number of protons in an element is known as its:

atomic number

if 1 proton, MUST be hydrogen
if 7 protons, MUST be carbon, etc.

Explain:

12 13
C C
6 6

top number is atomic mass or mass number

middle is the symbol for the element

bottom is atomic number

these are 2 isotopes of carbon

What is chemical energy?

energy stored in chemical bonds of molecules

ATP (adenosine triphosphate--made by mitochondria)

What is potential energy?

energy stored in matter because of its position

What are two types of potential energy?

- chemical energy
- electrical energy

What is electrical energy?

energy of charged particles stored in a particular location, such as a battery

energy derived from the flow of electrons

energy of charged particles (electrons) moving and creating a current

What is kinetic energy?

the energy of motion

What are three types of kinetic energy?

- heat
- electromagnetic energy
- electrical energy

What is heat?

the energy of molecular motion

What is electromagnetic energy?

the energy of moving photons, e.g., light

How are elements classified in the periodic table?

based on their chemical properties

What is the first law of thermodynamics?

energy can be neither created nor destroyed, but can be converted from one form to another

What is the second law of thermodynamics?

as energy forms convert form one form to another, the universe increases in disorder

What is an atom?

the basic unit of all matter

the smallest possible unit of matter that retains the physical and chemical properties of that element

nucleus and electron shell

The structure of an atom determines:

its chemical behavior

What are the subatomic particles?

neutrons (no charge)
protons (positive charge)
electrons (negative charge)

How are electrons arranged in the electron cloud/shell (for our purposes)?

2 maximum in innermost layer
8 maximum in second layer
8 maximum in third layer

What is the atomic number?

the number of protons in the nucleus

(it is also equal to the number of electrons, if the atom is neutral)

What is the atomic mass?

the sum of the number of protons and the number of neutrons in an atom

What is another term for atomic mass?

mass number

What is the atomic weight?

the average of the mass numbers of an element's isotopes

What are the energy levels of electrons?

arrangement of electrons in an atom into different layers (a.k.a. electron shells or orbitals)

electrons have potential energy due to their position relative to the nucleus of the atom

How many electrons can the first electron shell hold?

The second and third? (for our purposes anyway)

2 (K orbital)
8 (L orbital)
8 (M orbital)

The chemical behavior of atoms is determined by:

configuration of its electrons

What are valence electrons?

electrons in the outermost electron shell of the atom

What is the outermost electron shell of an atom called?

valence shell

How many valence electrons are in:
1) hydrogen, lithium, sodium, potassium
2) helium, calcium
3) carbon
4) nitrogen
5) oxygen
6) chlorine

1 - H, Li, Na, K
2 - He, Ca
4 - C
5 - N
6 - O
7 - Cl

The chemical behavior of atoms is determined by:

configuration of its electrons

Chemical bonds formed between atoms involve:

valence electrons

What is an isotope?

various atoms of an element that have the same number of protons (because that defines the element) but different numbers of neutrons

What are radioactive isotopes?

isotopes that are decaying to a more stable configuration

as they decay they emit radiation

some have medical uses:
Iodine-131 - check thyroid size/activity
Radium-226 - cancer radiation therapy

What is a half-life?

the amount of time for half of the radioactive isotope to decay and disappear

What are molecules?

two or more atoms chemically combined (forming bonds)

What are chemical bonds?

attractions between atoms that hold molecules together

What are three types of chemical bonds?

- covalent bonds
- ionic bonds
- hydrogen bonds

What are covalent bonds?

chemical bonds formed by atoms SHARING one or more pairs of electrons

What are two types of covalent bonds?

nonpolar covalent bonds - atoms share electron pair(s) equally

polar covalent bonds - atoms share pair(s) of electrons unequally (e.g., water)

What makes a covalent bond nonpolar?

the atoms share the electron pair(s) equally

e.g., H2 - each H atom needs one more electron to fill its valence shell; they each share their own electron equally because they are the same size and exert the same amount of pull on the electrons

What makes a covalent bond polar?

the atoms do not share the electrons equally

e.g., with water, O needs an electron from each H atom; as the O atom is so much larger, it exerts more force on the electrons, making that end of the compound slightly negative and leaving the H ends slightly positive

What is an ion?

a charged atom or molecule

What is an anion?

an atom that has gained one or more electrons from another atom and become negatively charged

e.g., Cl- (receiver, negative, anion) takes electron from Na

What is a cation?

an atom that has lost one or more electrons and become positively charged

e.g., Na+ (giver, positive, cation) gives electron to Cl

Are ionic bonds strong or weak?

weak

What is an ionic bond?

bond formed by the attraction between an atom with a positive electrical charge (cation) and an atom with a negative electrical charge (anion)

What is a hydrogen bond?

a bond formed when a covalently bonded hydrogen atom acquires a slight positive charge and becomes attracted to negatively charged atoms nearby

(because the H atom is so small it loses out in covalent bonding and becomes slightly positive)

Are hydrogen bonds weak or strong?

weak

A molecule's biological function is closely related to:

its shape

What is an electrolyte?

ions in solution

What are chemical reactions?

the process of making and/or breaking chemical bonds, which leads to changes in the composition of matter

What is on each side of the equation in a chemical reaction?

reactants -----> products

List six types of chemical reactions.

- synthesis reactions (anabolism)
- decomposition reaction (catabolism)
- oxidation (produces cation)
- reduction (produces anion)
- dehydration reaction (condensation reaction)
- hydrolysis reaction

What is another name for a synthesis reaction?

anabolism

What is a synthesis reaction (anabolism)?

combining 2 or more atoms or molecules to form a more complex one (e.g., A + B ---> AB)

stores (chemical/potential) in the bonds

What is another name for a decomposition reaction?

catabolism

What is a decomposition reaction (catabolism)?

breaking of chemical bonds to form 2 or more products (e.g., AB ---> A + B)

releases (chemical/potential) energy contained in the bonds

What is oxidation?

when an atom or molecule loses electrons or hydrogen ions

OIL - oxidation is loss (cation)

What is reduction?

when an atom or molecule gains electrons or hydrogen ions

RIG - reduction is gain (anion)

What is a redox reaction?

since oxidation and reduction reactions always occur together, that is what they are sometimes referred to as

What is dehydration synthesis/a dehydration reaction?

bonding molecules by removing water

anabolic process by which 2 molecules are chemically bonded through the use of enzymes and loss of water

glucose + glucose + enzyme = maltose + water + enzyme

What is another name for dehydration synthesis/reaction?

condensation reaction

What is hydrolysis?

breaking a bond by adding water (a gain of water)

catabolic process by which the bonds between monomers are broken by enzymes and the addition of water (you're breaking up the water and adding it in)

sucrose + water + enzyme = glucose + fructose + enzyme

By what means can one increase the rate of chemical reactions?

- concentration of reactants (increase)
- agitation
- size of particles (decrease)
- temperature (increase)
- enzymes as catalysts

CASTE

What makes a compound organic?

carbon (linked to hydrogen)

carbon alone, inorganic (e.g., CO2)

What are the properties of water?

- main regulator of homeostasis
- most abundant inorganic compound in the body
- approximately 62% of body is water
- very stable liquid at broad range of temperatures
- very polar molecule, thus it dissolves many substances

What is the main regulator of homeostasis?

water

what is the most abundant inorganic compound in the body?

water

Water is used in the body as:

- solvent
- temperature regulator
- transporter
- lubricant
- cushion

What causes surface tension in water?

hydrogen bonding that causes water molecules to stick together

What is a solution?

a liquid that is a completely homogeneous mixture of two or more substances

What is a solvent?

the dissolving agent of a solution

What is a solute?

the substance dissolved in a solution

What is an aqueous solution?

a solution in which the solvent is water

What is an acid?

a substance that releases hydrogen ions (H+) when dissolved in water

(e.g., HCl ---> H+ + Cl-)
a proton donor

What is a base?

a substance that accepts hydrogen ions (H+) or releases hydroxide ions (OH-) when dissolved in water

NH3 + H+ ---> NH4-
KOH ---> K+ + OH-

What is a salt?

a substance that releases a cation other than H+ and an anion other than OH- when dissolved in water

NaCl ---> NA+ + Cl-
KBr ---> K+ + Br-

product of an acid and a base
HCl + NaOH ---> H2O + NaCl

Acid + base =

salt (and water)

Another word for base/basic:

alkaline

What is the pH of blood?

What keeps it there?

7.35-7.45

buffers help maintain it

e.g., if you drink coffee, your blood will be temporarily acidic, then the buffers will intervene and bring it back in line

What is pH?

the expression of acidity or alkalinity of a solution

the negative log of the concentration of H+ expressed in moles per liter

What is the scale for pH?

a scale from 0-14 to measure the acidity or alkalinity of a solution

acidic from 0- <7
alkaline from >7-14
7 is neutral

What is an acidic solution?

a solution in which which the pH is greater than 0 and less than 7

the lower the number the more acidic the solution and the higher the concentration of H+

I think he said <= 5 is strong acid and above that was weak acid

What is a basic solution?

a solution in which the pH is greater than 7 and less than 14

the higher the number the more basic the solution because the concentration of H+ is lower

What is a neutral solution?

a solution in which the pH is equal to 7

the concentration of H+ is equal to the concentration of OH-, and is thus neutral

What are buffers?

chemical substances that regulate the changes in pH and therefore help maintain homeostasis in the body

buffers are weak acids or weak bases that are added to neutralize strong bases or strong acids

What is organic chemistry?

the study of organic compounds

What are organic compounds?

compounds that contain carbon and usually hydrogen
typically large and complex, and covalently bonded

e.g., carbs - CHO, proteins (COOH carboxyls), fats (C saturated w/H on glycerol), vitamins, DNA, RNA

What is an inorganic compound?

compounds that do not contain carbon bonded to carbon, or carbon bonded to hydrogen

e.g., water, minerals, CO2, oxygen, nitrogen

carbon alone is inorganic
lack of carbon is inorganic

Why are carbon atoms such versatile building blocks?

carbon has 4 valence electrons and needs 4 covalent bonds to complete its valence shell

this makes it possible for carbon to form large, complex molecules

What are the 6 categories of nutrients required by the body?

- carbohydrates (organic--CHO)
- proteins (organic--COOH carboxyl)
- fats (organic--C saturated w/H on glycerol)
- vitamins (organic)
minerals - inorganic
water - inorganic

Of what are carbohydrates comprised and what is their purpose?

CHO

carbo + hydrate = carbon + water

major source of energy for the body

How many types of carbohydrates are there, and what are they?

- monosaccharides
- disaccharides
- polysaccharides

What are monosaccharides?

"simple sugars" - the only sugar we can absorb

contain 3-7 carbon atoms

e.g., glucose, fructose, galactose

What are disaccharides?

"double sugars"

combination of 2 monosaccharides

e.g.,
sucrose = glucose + fructose
maltose = glucose + glucose
lactose = glucose + galactose

What are glucose, fructose, and galactose?

"simple sugars" = monosaccharides

all 6-carbon (hexose) but different structures (isomers)

What is an isomer?

variances in structure of a compound

same formula, different arrangement of atoms
(e.g., glucose and fructose are both hexose, but formed differently)

Why do sugars dissolve in water so readily?

their covalent polar bonds are easily broken in water

C6H12O6 = C + H2O

How are the bonds of disaccharides broken into monosaccharides so they can be absorbed?

by an enzyme

sucrase breaks the glucose + fructose bond of sucrose

lactase breaks the glucose + galactose bond of lactose

maltase breaks the glucose + glucose bond of maltose

What are polysaccharides?

combinations of more than 2 monosaccharides

e.g., starch, glycogen (in muscles & liver), cellulose, heparin (anticoagulant)

How are carboydrates catabolized?

from polysaccharides ----> disaccharides ---> monosaccharides with the use of enzymes at each step

What are lipids?

a combination of CHO, but in different ratios than carbohydrates

Lipids may contain other elements such as:

phosphorous and nitrogen

What are some lipid categories?

- triglycerides
- phospholipids
- steroids
- eicosanoids

What are triglycerides?

most abundant form of lipids, both in the diet and in the body

neutral fats (pH = 7)

3 fatty acids (saturated or unsaturated) on backbone of glycerol

What are saturated fatty acids?

- no carbon=carbon double bonds
- full of hydrogen (saturated)
- solid at room temperature b/c they are straight and stackable
- found in animal fat
- "slow killer"

What are unsaturated fatty acids?

- one or more carbon=carbon double bonds, where they bend
- bend prevents stacking, thus liquid at room temperature
- 1 bend = monounsaturated fat
- more than 1 bend = polyunsaturated fat

What are phospholipids?

the main component of cell membranes

composed of glycerol, 2 fatty acids, phosphate group

How do phospholipids form the cell membrane?

in a bilayer,
hydrophilic phosphorus heads facing out
hydrophobic lipid tails together

What are steroids?

lipids that are composed of four fused carbon rings

e.g., cholesterol, bile salts, testosterone, estrogen, progesterone, corticosteroid hormones (aldosterone, prednisone)

What are eicosanoids?

lipids that are chemical messengers between cells

Name some eicosanoids.

- prostaglandins - cause contraction of smooth muscles
- leukotrienes - involved in allergic and inflammatory responses
- thromboxone - clotting promoter

What is a protein?

a covalently bonded chain of (more than 100) amino acids

composed of carbon, hydrogen, oxygen, and always nitrogen

may contain sulfur, phosphorus, and iron

What are dipeptides, tripeptides, and polypeptides?

- a chain of 2 amino acids
- a chain of 3 amino acids
- a chain of 15-100 amino acids

and, of course, a protein is a chain of more than 100 amino acids

What are amino acids?

the building blocks of protein

central carbon bonded to:
- amino group (NH2)
- hydrogen (H)
- carboxyl group (COOH)
- variable side chain (R)

How many different "R" groups are there?

20, which means there are 20 different amino acids

What are essential amino acids?

How many are there?

those that cannot be manufactured by the body and must be consumed in the diet

9 (11?)

What are nonessential amino acids?

How many are there?

amino acids that can be manufactured in the body, and don't have to be consumed in the diet

11 (9?)

How are amino acids joined together?

by a peptide bond

dehydration reaction bonds carboxyl carbon (COOH) of one amino acid to the nitrogen (NH) of the next amino acid

How many levels of protein structure are there?

4
- primary structure
- secondary structure
- tertiary structure
- quaternary structure

What is the primary structure of a protein?

the list of the amino acids
also called the sequence of the amino acids

sequence is determined by the DNA in the nucleus of the cells

What makes you, you?

the DNA in the nucleus of your cells, which tells amino acids how to sequence to form proteins

Alterations in the sequence of amino acids may cause:

change in the functioning of the protein (which has serious consequences)

What is the secondary structure of a protein?

the twisting or folding of the chain of amino acids

What holds the secondary structure of a protein together?

hydrogen bonds

What are the 2 types of secondary structures of a protein?

alpha helix and beta sheet (pleating)

What is the tertiary structure of a protein?

folding and coiling of the protein chain into an overall globular shape due to interactions between "R" groups or between "R" groups and water

What types of bonds form tertiary structures?

covalent and/or ionic

What is the quaternary structure of a protein?

interaction of two or more polypeptide chains to form a complete protein

All 4 levels of protein structure must be maintained for the protein to _____ ____.

function properly

What is the key to a protein's function?

the protein's conformation (shape)

What is denaturation of a protein?

drastic change in the conformation of a protein which may render it useless for its original function

How may proteins be denatured?

by changes in

- temperature (e.g., cooking egg white)
- pH change

What are some types of proteins?

- antibodies (protect against disease)
- hemoglobin (carry oxygen in blood)
- enzymes (control chemical activity)
- polypeptides (many amino acids bound together)

What do enzymes do?

- speed up rate of chemical reactions in the body by lowering the amount of activation energy needed
- can be reused--are not consumed or permanently changed in the reaction
- are very substrate-specific

also called catalysts

What are nucleic acids?

organic compounds composed of nucleotides

(so named b/c they are in the nucleus of every cell)

What are the three components of nucleotides?

- one or more phosphate groups
- a 5-carbon sugar (ribose or deoxyribose)
- nitrogenous base

What are the nitrogenous bases associated with DNA? What changes in RNA?

(The Pyrimidines)
- cytosine (C)
- uracil (U) - RNA
- thymine (T) - DNA

(The Purines)
- adenine (A)
- guanine (G)

-C-
UT = Pyrimidines

Purines - AG

DNA is the major component of:

chromosomes, the hereditary information contained in the nucleus of cells

DNA controls:

activity of cells by controlling protein synthesis

DNA is a double-stranded helix with what type(s) of bonding?

- covalent bonds between the components of the nucleotides and

- hydrogen bonds between the nitrogenous bases to hold the 2 strands together

Which nitrogenous bases bond in DNA? In RNA?

DNA -
-- adenine with thymine, and
-- cytosine with guanine

RNA -
-- adenine with uracil
-- cytosine with guanine

The sequence of nucleotides determines:

heredity

A change in DNA sequence (mutation) may produce:

a hereditary change

(not all mutations change the final product--the protein)

What sugar is contained in DNA? In RNA?

- deoxyribose

- ribose

What is RNA?

a single-stranded molecule involved in protein synthesis in cells

What are the 4 main types of RNA?

- messenger RNA (mRNA)
- transfer RNA (tRNA)
- ribosomal RNA (rRNA)
- nuclear RNA (nRNA)

What is ATP?

adenosine triphosphate

the energy molecule for cells

How do cells use ATP?

cells store energy as ATP and use it to perform cell functions

when needed, ATP is hydrolyzed using enzymes to form ADP and an inorganic phosphate group (triphosphate to diphosphate)

ATP + H2O ---->

ADP + Pi + energy for work/heat

Of what is ATP composed?

- adenine
- ribose (5-carbon sugar)
- 3 phosphate groups (tri-)

Where is ATP manufactured?

most ATP is synthesized in the mitochondria in a series of reactions called cellular respiration

The smallest quantity of an element which still reflects or possesses its characteristic is called:

an atom

If someone decided to starve himself, he would likely develop

metabolic acidosis

What is respiratory alkalosis?

too much CO2 elevates blood pH

caused by hyperventilating

The most abundant polysaccharide in our diet is

starch

We cannot digest cellulose, but why do we need it in our diet?

it is the dietary fiber needed to assist digestion and it becomes the bulk that assists bowel movements

Why are some people lactose intolerant?

they lack an adequate amount of the enzyme lactase and therefore cannot break lactose down into its usable monosaccharide components

When the liver synthesizes glycogen from glucose, the process is

anabolism or catabolism?

anabolism

Dehydration reaction derives from

a. anabolism
b. catabolism
c. glycolysis
d. decomposition

anabolism

The linear sequences of amino acids gives rise to _____ ______ structure.

three dimensional

All proteins contain carbon, hydrogen, oxygen, and nitrogen. (T/F)

true

Are lipids hydrophobic or hydrophilic? Substantiate your answer.

hydrophobic

they are insoluble in water due to their nonpolar covalent bonds

The basic unit for nucleic acids is ________

nucleotides

What are the components of a typical nucleotide?

- nitrogen base,
- 5-carbon sugar called deoxyribose or ribose, and
- phosphate group

What nucleic acid is made up of a fragment of genes?

DNA

Name four organic macromolecules.

- carbohydrates
- proteins
- lipids
- vitamins

Two examples of eicosanoids:

- prostaglandins
- leukotrienes

Is prostaglandin a lipid?

yes

All enzymes are carbohydrates? (T/F)

false, they are proteins

Are enzymes useful for chemical reaction?

yes, because almost all chemical reactions in a biological cell need enzymes in order to occur at rates sufficient for life; enzymes are proteins that catalyze (increase the rates of) chemical reactions; in enzymatic reactions, the molecules at the beginning of the process (substrates) are converted into different molecules, called products

they lower energy needed for reactions

What molecule, produced in the mitochondria, generates energy?

ATP (adenosine triphosphate)

Give 2 examples of hexose.

6-carbon sugar

galactose and glucose

What is the purpose of RNA?

protein synthesis

What is the purpose of DNA?

genetic material

List some lipids

- triglycerides (saturated and unsaturated fatty acids)
- phospholipids
- steroids
- eicosanoids

What is a gene?

a segment of DNA