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17 Cards in this Set
- Front
- Back
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Linkage and how to detect it.
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It's difficult
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Mendel was extremely lucky
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Because he chose expression that is expressed. Well, now lying is a wise choice in science.
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mapping
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case study for a memory loss 74 old man and personality changes.
Huntington's disease <- was the doctor's assumption. |
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Huntington diesease
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huntintin diesease
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Expanded pedigree of a family with huntington's disease.
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compare with 2 more families, one w and one w/out the disease.
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When there is n olinkage, parental and recombinant progeny are expected in equal proportions
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Which mean that when we do have a test cross
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Norgan's lab discovers linked traits in fruit fly
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Pr and pr+
Normal and vestigal wing |
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Test cross dihybrid female (pr+/pr.vg/vg+) with tester male (pr/pr.vg/vg)
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The results show that those genes are linked
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chiasmata and chiama
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the point where two homologous non-sister chromatids exchange genetic material during chromosomal crossover during meiosis
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Linked gene shows that
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almost same amount of recombinant and parental.
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knob and long arm in corn's chromosome
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=> exchange and recombinant during meiosis 1 :love2:
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Alfred Sturtevant.
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the sophomore who invented the genetic map
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He says
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For ever % he call the it a Morga unit
10% recombinant = 10cM |
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He also thinks
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map units are additive
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mapping is
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a multibilion agricultural industry
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Mapping 2 traits is labourious
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So we use th ethree point testcross
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example
Vermillion eye, veinous and cut wings |
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v+/v+.cv/cv.ct/ct x v/v.cv+/cv+.ct+/ct+ F1 trihybrid See the result. |
