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12 Cards in this Set
- Front
- Back
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Where are common sites for biofilm formation?
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Implanted devices
Catheters (contaminants) Gums (disease) |
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What is a complication secondary to biofilm formation?
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Detachment of cells causing bactermia, emboli
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What is the protective mechanims of biofilms against macrophages?
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Physical shielding of bacterial from phagocytes, antibodies, complement, and antibiotics
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What is the problem with treating biofilms with antibiotics?
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You can't kill all the cells - "persister" cells will reseed the population after the antibiotics are discontinued
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Are cells within biofilms homogenous?
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NO!
There are many different cell types (matrix producers, spores, miners, etc.) |
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What is the mechanism of communication within biofilms? What molecules complete this communication?
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Quorum sensing
Small molecules called "auto inducers" |
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What is the prototypic example of quorum sensing?
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The bobtail squid
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What is the cause of light in the bobtail squid?
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Vibrio fischeri
Formation of light at high enough concentration at night-time when at stationary phase |
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What are stimuli that can cause biofilm formation?
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Autoinducers from other bacteria
Autoinducers from the gut Antibiotics |
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What types of drugs inhibit quoroum sensing?
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Furanones
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What is the origin of macrophage resistance in bacteria?
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Amoebae
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What type of gram positive bug normally forms biofilms on Catheters?
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S. aureus
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