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17 Cards in this Set
- Front
- Back
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Erythron
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line of cells from recognizable erythropoietin-responsive stem cell to red cell
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reticulocyte
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- the last stage before RBC formation
- have no nuclei |
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anemia
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deficiency in red cells, deficiency of Hb, or deficiency of both
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Name the hormone that trigger differentiation of stem cells to RBCs
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Erythropoetin
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Where is EPO synthesized?
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kidney
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What stimulus provokes the release of EPO?
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Produced in response to hypoxia
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What are the ABH antigens?
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Antigens found on blood cells which differentiate to different blood types
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What are the products of ABH genes?
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Blood type O - just H antigen
Blood type A - A antigen Blood type B - B antigen |
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What's so special about the red cell's shape?
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- shaped like biconcave disk
- allows RBCs to squeeze into small spaces such as capillaries |
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What organ normally removes RBCs from circulation?
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Most often by: spleen
Less often by: liver and bone marrow |
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What age are RBCs removed from circulation?
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End of RBC life span - 120 days
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Name 3 major metabolic capabilities that red cells LACK
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Dunno - let me know if you guys can find this answer
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How is G-6-P dh deficiency usually first observed in a patient?
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When a patient is given one of the anlimlarials and then develops hemolytic anemia
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How does 2,3-BPG affect hemoglobin function?
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2.3-BPG decreases the affinity of Hb for oxygen
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Describe how membrane band 3 acts as an oxygen sensor to vary the activities of glycolysis and the pentose phosphate pathway
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Band 3 acts as O2 sensor - directs antioxidant production when O2 is high and ATP production when O2 is low
How? When [O2] high --> binding of glycolytic enzymes to band 3 favored, and since binding to band 3 inhibits their activity: glycolysis slows and more glucose metabolized via PPP When [O2] falls --> increased amounts of deoxyHb bind to band 3: glycolytic enzymes released, inhibition is relieved, metabolism of glucose by glycolysis can occur |
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Name as many causes of anemia as you can
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Deficient Hb synthesis
iron deficiency erythropoietin lack aplastic anemias premature red cell destruction |
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What is the source of the CO2 produced by red cells?
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???
Couldn't find this one either |
