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75 Cards in this Set
- Front
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Second name for:
1- Vit A. 2- Vit D. 3- Vit E. 4- Vit K. 5- C. 6- B1. 7- B2. 8- B3. 9- B6. 10- H. 11- B12. |
Retinoids.
Sterols(Cholecalciferol) Tocopherols napthoquinones L-Ascrobic Acid Thiamine Riboflavin Niacin Pyrodoxin Biotin Cyanocobalamin |
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Polyisoprenoid
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A
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Isoprenoid side chain
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E
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# tocopherols
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8
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The name of the ring in:
A D E B1 B2 H Folic Acid B12 |
Beta-Ionone
Cholesterol Tochol or Chromane Pyrimidine & Thiazol isoalloxathine Imidazol Pteridine & PABA Corrin |
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Tochopherols enter the lymphatics bound to
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Chylomicrons & other lipoproteins
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Transport in blood:
A E |
RBP
Lipoprotein |
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Alpha tocopherols are important because:
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Widest distribution
Greatest biological activity |
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RDA E:
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4 IU
12-15 IU |
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RDA k2:
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50 microgram
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Tocopherols act synergistically with
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Selenium
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Defici. E:
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1- Hemolytic Anemia.
2- Muscle weakness. |
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Hypervitaminosis E
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Hemorrhage
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Rat Antisterility
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E
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Funct. E:
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Prevents hepatic necrosis
enhances immune response |
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Side chains K1, K2
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20
30 |
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K3
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Menadione
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manandione's clinical importance
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Water-soluble
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K flora:
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k2
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Poor souces of K
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Animal sources
Fruits |
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Funct. K:
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Regulates synt. of prothrombin
Pro-convertin Stuart-prower Christmas factor |
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Prothrombin --> thrombin
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Carboxylation of Gamma glutamte of prothrombin
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inhibit hydroquinone:
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Warfarin
Dicumarol |
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Oxidative phosphorylation
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K
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Newborn's deficiency
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K
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Hyp.vit. K
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Hemolysis
hyperbilirubinemia brian damage |
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Reduc. Fehlin & Bened
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L-Ascrobic acid
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Similar to sugars
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L-ascorbic acid
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Methemoglobin --> hemoglobin
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C
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Antioxidants
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C
E Beta-carotene |
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Decreases risk of cataract
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Vitamin C
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Weak bones, easily fructured:
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C
D |
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Whole Grains
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B1
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RDA thiamine:
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1.5 mg/day
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TPP
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Oxidative decarboxylation
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Deficiency of thiamine:
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BeriBeri
Wernicke's-Korsakoff |
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Tachycardia
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Thiamine
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Oothalmoplagia:
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Paralysis of ocular muscles
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Alcoholics
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B1 Defic.
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Decomposes by visible light:
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Riboflavin
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RDA riboflavin
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1.5-2 mg/day
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flavo-protein enzyme:
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FAD
FMI |
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Protheric groups of oxidoreductase:
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FMN
FAD |
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Hydrogen Carriers
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Flaviproteins
FMNH2 FADH2 |
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Transketolase
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Thiamine
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FMN:
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Oxidate deamination
ATP-> oxidative phosphorylation |
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FAD
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Carbohydrate metabolism
Lipids metabolism Some AAs |
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Riboflavin deficiency:
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Angular stomatitis
Inflammed lips Glossitis Scally dermatitis |
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60 MG tryptophan
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Niacin
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RDA Niacin:
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20 mg
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Coenzyme niacin:
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NAD
NADP NMN |
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NAD
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Lactate dehydrogenase
Pyrruvate dehydrogenase |
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NADP
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Folate reductase
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Tryptophan->serotonin
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Carcino syndrome
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Pellagra
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Niacin deficiency
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3Ds
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Dermatitis
Diarrhea DementiaB6 |
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Pyrodoxine
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b6
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Pyridine in urine
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oxidized perodoxic acid
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Most active Co of B6
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Pyrodoxal phosphate
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RDA B6
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6 mg/day
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Carbon Moiety
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H4F
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Biosynthesis of DNA
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H4F
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Alcoholics
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Folic Acid
B6 B1 |
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Hemocystein -> methionine
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B6
B12 H4F |
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Folate antagonists:
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methotrexate
sulfanamide trimethotropin |
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Cobalt contain. vit
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Cyanocobalamin
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Vegetarian's deficiency
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B12
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Flora
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K2
B12 Biotin |
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Cobalamin binds to
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Intrinsic factor
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Transportation B12 blood
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TCII
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Coenzyme of B12
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Cobamide
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Pernicious anemia
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B12
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Pentoic acid + beta alanine:
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Pantothenic acid
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Sulfur containin:
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A
Lipoic Acid pantothenic acid |
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Oxidative decarboxylation:
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lipoic acid
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