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17 Cards in this Set
- Front
- Back
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At what point in glycolysis can the intermediates enter the Pentose Phosphate Pathway?
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1. G6P
2. F6P and G3P can enter the shunt going backwards |
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What two enzymatic reactions will yield NADPH in the PP Pathway?
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1. Glucose-6-phosphate dehydrogenase
2. 6-Phosphogluconate dehydrogenase |
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What enzyme in the pentose pathway will release a CO2 as a product?
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6-phosphogluconate dehydrongenase
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What is the end product of the oxidative stage of the pentose phosphate pathway?
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Ribulose-5-Phosphate
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What is the function of gluconolactonase? Why is it important?
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1. To break the lactone bound that spontaneously forms in 6-phosphogluconate
2. Accumulation of 6-phosphoglucolactone is toxic |
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What are the two fates of Ribulose-5-phosphate?
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1. Xylulose-5-phosphate (X5P)--epimerase
2. Ribose-5-phosphate (R5P)-- isomerase |
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What are the reactants and products of transaldolase?
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1. Sedoheptulose-7-phosphate and Glyceraldehyde-3-phosphate
2. Fructose 6-phosphate and Erythrose 4-phosphate |
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There are two transketolase reactions in PPP. What are they?
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1. X5P and R5P to make S7P and G3P
2. X5P and E4P to make F6P and G3P |
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What are the end products of the PPP, if there is no need for ribose?
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2 F6P and 1 G3P
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Which enzyme in the PPP requires TPP (Vitamin B1)? What mutation can be caused without TPP?
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1. Transketolase
2. Wernicke-Korsakov also called wet brain (Thiamine deficiency, beri beri, seconday to alcohol abuse). K. Psychosis and W. encephalopathy. |
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Why does the body require NADPH?
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1. Maintenance reduction power: Fe for hemoglobin and Cysteine bridges
2. FA and cholesterol synthesis 3. To make deoxy-ribose |
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Pyruvate has 4 possible fates. Name them.
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1. Made into alanine
2. Made into acetyl-CoA and enter TCA 3. Made into acetyl-CoA and used in FA synthesis 4. Made into lactate |
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What enzyme will breakdown ethanol into acetaldehyde?
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Alcohol dehydrogenase
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What enzyme will yield acetic acid from acetaldehyde?
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Acetaldehyde dehydrogenase
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What is the end product of ethanol metabolism?
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Acetyl-CoA
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How many NADH do you get from metabolism of ethanol to acetal-CoA?
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2 NADH
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How many ATP can you get from one ethanol molecule?
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2 NADH + 1 Acetal-CoA
1 Acetal-CoA= 12 ATP Total of 18 ATP per ethanol. |
