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14 Cards in this Set
- Front
- Back
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describe the fate of pyruvate under anaerobic
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forms lactate thru the lactate dehydogenase enzyme
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Explain the role of thiamine pyrophosphate(TPP)
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Its a coenzyme derived from vit B1 that carries "Active Acetoaldehyde" groups
It aids in ethanol fermentation, synthesis of acetyl-CoA in citric cycle and aids in carbon assimilation rxns of the pentos phosphate pathway |
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what can a vit B1 deficiency cause
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beriberi
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describe the ethanol fermentaion process
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Pyruvate is first converted to Acetylaldehyde thru pyruvate decarboxylase enz along with TPP and Mg2+ as "coenzymes" and CO2 is given off. Then acetaldehyde is converted to ethanol thru alcohol dehydrogenase by oxidation of NADH+ + H+ to NAD+
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how many grams of glucose does the brain require per day
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120, but only 60g can be stored in our body
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T or F Gluconeogensis is the exact reverse of glycolysis
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F, due to large -delta G of 3 steps in glycolysis
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give the relationship between Keq and Delta G
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Keq > 1.0 then G is negative rxn goes fwd
Keq = 1.0 then G is zero rxn in equil. Keq < 1.0 then G is positive rxn goes in reverse |
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T or F all enzymes used in glycolitic pathway are found in the mitoch
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F, they are all found in cytosol
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T or F all enzymes used in gluconeogenesis are found in the cytosol
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F, 2 of them are found in mitchondria
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What are the 3 bypass reactions in gluconeogenesis
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1 - pyruvate converted to phosphoenolpyruvate thru pyruvate carboxylase enzyme found in mitochondria
2 - Conversion of fructose 1,6 Bisphosphate to Fructose 6-phosphate 3 - glucose 6-phosphate converted to glucose |
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What substrate is a potent regulator of both glycolysis and gluconeogenesis
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Fructose 2,6-Bisphosphate
lots of above molecule leads to activation of glycolysis |
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describe the 2 branches of pentose phosphate pathway
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Oxidative phase- production of NADPH
Non oxidative phase- |
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What is the role of NADPH in partioning glucose 6-phosphate between glycolysis and pentose phosphate pathway
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as you push oxidative path of ribose phosphate pathway lots of NADPH is produced which inhibits the pathway- i get negative feedback from this but it wasnt stated in lecture, he covered it shitily
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of the two enzymes transketolase and transaldolase which one uses TPP to proess its substrates
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Transketolase
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