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14 Cards in this Set

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describe the fate of pyruvate under anaerobic
forms lactate thru the lactate dehydogenase enzyme
Explain the role of thiamine pyrophosphate(TPP)
Its a coenzyme derived from vit B1 that carries "Active Acetoaldehyde" groups

It aids in ethanol fermentation, synthesis of acetyl-CoA in citric cycle and aids in carbon assimilation rxns of the pentos phosphate pathway
what can a vit B1 deficiency cause
beriberi
describe the ethanol fermentaion process
Pyruvate is first converted to Acetylaldehyde thru pyruvate decarboxylase enz along with TPP and Mg2+ as "coenzymes" and CO2 is given off. Then acetaldehyde is converted to ethanol thru alcohol dehydrogenase by oxidation of NADH+ + H+ to NAD+
how many grams of glucose does the brain require per day
120, but only 60g can be stored in our body
T or F Gluconeogensis is the exact reverse of glycolysis
F, due to large -delta G of 3 steps in glycolysis
give the relationship between Keq and Delta G
Keq > 1.0 then G is negative rxn goes fwd
Keq = 1.0 then G is zero rxn in equil.
Keq < 1.0 then G is positive rxn goes in reverse
T or F all enzymes used in glycolitic pathway are found in the mitoch
F, they are all found in cytosol
T or F all enzymes used in gluconeogenesis are found in the cytosol
F, 2 of them are found in mitchondria
What are the 3 bypass reactions in gluconeogenesis
1 - pyruvate converted to phosphoenolpyruvate thru pyruvate carboxylase enzyme found in mitochondria
2 - Conversion of fructose 1,6 Bisphosphate to Fructose 6-phosphate
3 - glucose 6-phosphate converted to glucose
What substrate is a potent regulator of both glycolysis and gluconeogenesis
Fructose 2,6-Bisphosphate

lots of above molecule leads to activation of glycolysis
describe the 2 branches of pentose phosphate pathway
Oxidative phase- production of NADPH


Non oxidative phase-
What is the role of NADPH in partioning glucose 6-phosphate between glycolysis and pentose phosphate pathway
as you push oxidative path of ribose phosphate pathway lots of NADPH is produced which inhibits the pathway- i get negative feedback from this but it wasnt stated in lecture, he covered it shitily
of the two enzymes transketolase and transaldolase which one uses TPP to proess its substrates
Transketolase