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28 Cards in this Set
- Front
- Back
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What is deposition of the platlet plug followed by?
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It is followed by a blood clotin order to construct a strong seal and provide a good foundation
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What cell is involved in the first part of wound repair and what do they do?
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Start with a platlet plug to build an intial barrier.
Activated platlets sectrete the cytokines PDGF, TGF-Beta, EGF, and IL-1 which signal that the need for tissue repair |
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What does fibrin do?
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Provides surface to which thrombin is attached and more platlets can bind and become activated
Fibrin is also involved in fibrinolysis which contributes to te disslution of blood clots |
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How does inflammation start?
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With the attraction of neutrophils to the wound site
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What do patients with factor XIII defiecncy suffer from
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From closed woulnd dehiscence and subsequent infections
The wounds heal very slowly b/c of the lack of cross-linking by fibrin |
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What causes pain?
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PGE2 and Bradykinin from arachidonic acid pathway
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What attracts neutrophils?
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LTB4
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What induces inflammation?
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PGE2 and Neutrophils which are induced by LTB4 and the cytokines from platelets (PDGF, EGF, IL-1, TGF)
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Three key components of hemostatic wound repair
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Aggregated Platlets
Cross-linked fibrin Arachidonic Acid Pathway |
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Three key components in the inflammatory phase of wound healing
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Thrombus
Neutrophils Cytokines |
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What does plasma contain as compared to serum?
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Plasma contains all coagulation factors and serum contains the growth factors
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PDGF
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Made by platlets
Important in dimerization which triggers autophosphorylation Chemotaxis Contraction of fibroblasts and s. muscle Activation of NEUTROPHILS |
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What cell invades early
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The neutrophil followed by macrophages
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What important pathway is lead to b/c of PDFG dimerization/autophosphorylation
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The phosphorylation of the MAP-K cascade which leads to increased gene activation and cell divisition
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TGF-Beta
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Involved in almost every step of wound repair
Inhibitroy to some cytokines |
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EGF
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Causes reepithelialization
Made by platlets |
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VEGF
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Key in angiogenesis
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KAF
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Proliferation of keratinoctes
the outer layer of skin late in the repair process |
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Fibroblasts
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Workhorse of tissue repair
Responsible for the synthesis and deposition of cllagen, elastin, proteoglycans, and other ECM components |
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Monocytes
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Infiltrate after neotrophils some time during ganulations tissue formation
They are procoagulation and they are janitorial in removal of dedbris from the dissolution of clots by fibrinolysis |
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What mainly causes the proliferation of smooth muscle cells
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PDGF made from platlets
They synthesize the ECM |
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What sends signals to inform cells of reapair
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Collagen and Elastin and Proteoglycans
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What is a possible effect of inhibiting angiogenesis
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May decrease cancer growth
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What can occur because of to much collagen synthesis during wound healing?
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Formation of a keloid
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What is responsible for the synthesis of to much collagen
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TGF beta
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What must occur at the end of the wound healing process and what does it
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Reorganization/resynthesizing of collagen done by the remolding work of MMP
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What is associated with stress and in wound repair
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Stress is associated with a negative effect on wound repair slowing it down
Associated with lower levels of IL-1 and IL-8 |
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What is associated with multiple injusrys to one area?
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Increased risk of atherosclerosis, which could lead to a Myocardial Infarction
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