Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
36 Cards in this Set
- Front
- Back
|
Thyroid stimulating hormone (TSH) has its target tissue, ______________ and its major response is _________.
|
thyroid, thyroid hormone synthesis and secretion
|
|
|
Adenocorticotropic hormone (ACTH) has its target tissue, ____________ and its major response is __________.
|
adrenal cortex; cortisol synthesis and secretion
|
|
|
Luteinizing hormone (LH) has its target tissue, ___________ and its major response is _______________.
|
ovary; progesterone secretion
|
|
|
adrenaline (epinephrine) has its target tissue, _______________ and its major response is ______________.
|
heart, muscle, fat; increase in heart rate or force of contraction and triglyceride breakdown
|
|
|
adrenaline, ACTH, glucagon and TSH all act on _____________ with a response of ______________.
|
fat; triglyceride breakdown
|
|
|
Glucagon has its target tissue, ___________ and its major response
|
liver; glycogen breakdown
|
|
|
parathyroid hormone (PTH) acts on ____________ and its major response is ________________.
|
bone; bone resorption
|
|
|
Vasopressin acts on the _____________ and its major response is _____________________.
|
kidney; water resorption
|
|
|
Isoproterenol is an (agonist/antagonist) and Propranolol is an (agonist/antogonist) on the beta-catecholamine receptor (epi receptor)?
|
agonist; antagonist
|
|
|
Name two beta blockers
|
inderal, propranalol (antagonists)
|
|
|
T or F: beta blockers are antagonists of epinephrine and its receptor?
|
True
|
|
|
What is the name of the epinephrine (adrenaline) receptor?
|
beta catecholamine
|
|
|
What 4 things do beta blockers treat
|
hypertension, migraines, PTSD and some cardiac problems
|
|
|
What is PKA?
|
phosphokinase A
|
|
|
Gsalpha self inactivates by the exchange of GTP for _________?
|
GDP
|
|
|
What causes the exchange of GDP for GTP on Gsalpha?
|
Binding to a hormone receptor
|
|
|
Gsalpha activates which protein?
|
Adenylyl cyclase
|
|
|
Does cholera toxin activate or deactivate Gsalpha? What is the result?
|
It keep Gsalpha active resulting is constant activation of adenylyl cyclase
|
|
|
Binding of BARK and subsequently causes epinephrine receptors to move from the membrane to _____________? This process would make the cell (more/less) sensitive to epinephrine?
|
endolytic vesicle; less (loss of receptors on membrane = cell can't see epi)
|
|
|
PLC activation results in _______________?
|
breakdown of lipis
|
|
|
PIP2 is broken down into two products, what are they?
|
DAG and IP3
|
|
|
Which phosphokinase is active in the PLC pathway?
|
PKC
|
|
|
IP3 causes ________________?
|
Release of intracellular Ca++
|
|
|
Release of intracellular Ca++ has two responses, name them in chronological order (ok, any order).
|
Regulation of other enzymes (by Ca++); Activation of protein kinase C
|
|
|
DAG causes _______________?
|
Activation of protein kinase C
|
|
|
Activation of protein kinase C causes __________________?
|
regulation of other enzymes by protein phosphorylation
|
|
|
T or F: Both DAG and IP3 remain membrane bound.
|
False, DAG remains bound to membrane while IP3 is freely soluble in the cytosol.
|
|
|
IP3 binds to a receptor on the membrane of which organelle?
|
ER
|
|
|
The binding of IP3 to its intracellular receptor causes _____________
|
release of Ca++ from the ER
|
|
|
Phosphotidylinositol turnover signaling pathway is responsive to which hormones? (5)
|
Acetylcholine, histamine, vasopressin, angiotensin and platelet-derived growth factor
|
|
|
Hormones which activate the Phosphotidylinositol turnover signaling pathway act by _____________.
|
Activating PLC, which degrades PIP2 to IP3 and DAG
|
|
|
T or F: PLC can only be activated via a G protein mechanism.
|
False, it can also be activated through tyrosine receptor pathways.
|
|
|
A serine/threonine specific protein kinase is activated by release of __________ from the _____________.
|
Ca++; ER
|
|
|
The serine/threonine specific protein kinase activated downstream of PLC is called _____________________.
|
Calmodulin-dependent protein kinase
|
|
|
What process negatively inhibits the phosphotidylinositol turnover pathway?
|
Metabolism of its second messengers, DAG and IP3
|
|
|
What can mimic (agonist) DAG in activating protein kinase C?
|
phorbol esters
|
