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15 Cards in this Set
- Front
- Back
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When iron is transferred in the blood it is bound to what?
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Transferrin
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What role does iron play in forming reactive oxygen species? Why is this a problem?
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Free iron can form reactive oxygen species through the Fenton reaction. ROS can react with lipids, proteins and DNA affecting cell function and causing tissue damage.
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What are the two main functions of transferrin?
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It binds free iron which keeps the plasma labile iron levels low, preventing the formaiton of ROS. Also, it reduced iron available for the growth of microbial pathogens.
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Reducing substances, such as Vitamin C, _________ iron absorption.
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Increase
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Fe2+ is transported into the enterocyte by ____________.
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Divalent metal trasnporter (DMT1)
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Within the enterocyte, Fe2+ can be oxidized and bound to ________ or trasnported out into circulation by _________.
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Ferritin, Ferriportin.
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In the circulation Fe2+ is oxidized to Fe3+ by ________ where it can be bound to transferrin or become part of the labile pool.
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Hephaestin (Hph)
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Peptide made in the liver that plays a major role in iron hemostasis.
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Hepcidin
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Binds to ferriportin and promotes its internalization and degradation.
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Hepcidin
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is a transmembrane protein that transports iron from the inside of a cell to the outside of it. It is found on the surface of cells that store or transport iron.
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Ferroportin
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Iron overload with a primary hereditary cause:
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Hemochromatosis
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Increasing hepcidin has what effect on iron absorption?
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It decreases iron absorption. More iron in the cell, less in circulation, more iron lost when cells slough off in GI tract.
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________ works to increase the iron levels in circulation.
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Ferriportin
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An increase in ferriportin leads to _______ loss of iron.
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Increased, lower level of iron in the blood.
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Factors that decrease body iron or increase its utilization would ______ hepcidin levels. What does this result in?
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Decrease, results in increased iron uptake, which decreases levels in the blood.
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