• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/59

Click to flip

59 Cards in this Set

  • Front
  • Back
Cell fragments formed from megakaryocytes
Platelets
Form the initial hemostatic plug
platelets
Which two things are first expressed on the exposed subendothelial surface
Collagen and Von Willebrand Factor
Which three things are released from vesicles within the platelets when adhesion begins?
1. Serotonin 2. Thromboxane A2 3.ADP
Which three proteins fascilitate platelet-platelet interactions during platelet deposition on the damaged surface?
1. von Willebrand Factor 2.Fibronectin 3. Vitronectin
Asprin works at the level of what?
Thromboxane A2 Production
Plavix interferes with:
ADP Signaling
Is driven by factors present in circulating blood
intrisic pathway
Depends on a factor derived from tissues
Extrinsic pathway
Initiates clot formation
Extrinsic pathway
---------- is exposed upon rupture of the endothelial lining of the blood vessel
Tissue Factor
TF complexes with which other factor to activate it?
VII
TF and Factor VII activate which other factor
X -> Xa
Xa combines with which other factor?
V
Factors Xa & V convert what to what?
Converts Prothrombin to Thrombin
Thrombin further activates the intrinsic pathway by converting which two factors?
V and VII
Thrombin activates which factor of the intrinsic pathway?
VIII
Activated thrombin also converts _______ to _______ which aggregate and form structural components of the clot.
Fibrinogen to Fibrin
These linkages form covalent crosslinks between fibrin monomers, hardening the clot
isopeptide linkages between the amide of glutamine and amino group of lysine
Which factor creates a catalytically active transglutamninase that assists in hardening a blood clot?
XIII
This protein is a hexamer comprised of three subunits (alpha, beta, and gamma) each present twice:
Fibrinogen
The six polypeptide chains of fibrinogen are held together by what kind of bonds?
Disulfide
The ________ are highly negatively charged and extend from the central domain of fibrinogen as frayed ends.
N-terminal ends, located in the middle of 3 globular domains
Active _________ cleaves the frayed ends of fibrinogen, resulting in the aggregation of fibrin molecules
Thrombin
Several proteins in the coagulation pathway contain the modified amino acid ________.
Gamma Carboxy glutamic acid (Gla)
Gla residues bind _____ and this interaction is critical for the functions of proteins containing Gla.
Calcium
Formation of Gla residues requires________.
Fat soluble vitamin K
Which two drugs act as analogs of vitamin K and inhibit blood clotting?
Warfarin & Dicoumarol
Vitamin K _________ inhibits the clotting process:
Deficiency
This pathway accelerates clot formation:
Intrinsic pathway
The extrinsic and intrinsic pathways converge at the activation of factor ____.
X
Hemophilia A is caused by a deficiency in which factor?
VIII
Factor VIII is stabilized in the serum by association with :
soluble von Willebrand Factor
Hemophilia B (Christmas Disease) is caused by a deficiency in which factor?
Factor IX
Interference in _________ can lead to thrombi, clots, and infarctions.
anticoagulation
An integral membrane protein found on the endothelial cell surface that is involved in the activation of protein C.
Thrombomodulin
Changes the structure of thrombin so that it no longer effciently cleaves fibrinogen
Thrombomodulin
Is modified to cleave protein C to Ca, instead of fibrinogen
Thrombin
Protein Ca complexes with cofactor S to inactivate factors __ & ___.
Va & VIIIa
Defiencies in factors _____ &_____ are rare but can increase the risk of venous thrombosis.
Factors C & S
A mutation in factor V that renders it resistant to inactivation by __________.
Factor V/Leiden, protein Ca
A relatively common mutation associated with venous thrombosis.
Factor V/Leiden
Antithrombin inhbits the activity of which three things
1) Thrombin 2) Factor IXa
3) Factor Xa
Is a member of the SERPIN (Serine protease inhibitors) family of proteins:
Antithrombin
Antithrombin's activity is substantially enhanced by _______.
Heparin
Antithrombin III deficiency is associated with an increased risk of __________.
Venous thrombosis
Heterogenous group of polysaccharides, all of which bind antithrombin:
Heparin
High molecular weight heparins have a preference for _______.
inhibiting thrombin
Low molecular weight heparin has a prederece for inhibiting _____.
Factor Xa
Fibrinolysis is driven by the activation of which proteolytic enzyme?
Plasmin
Which protein activated during the anticoagulation phase degrades plasminogen activator inhibitors (PAI)?
Protein C
Proteolytic enzyme that converts plasminogen to plasmin.
Tissue Plasminogen Activator (t-PA)
Degrades fibrin present in the clot to soluble fibrin fragments.
Plasmin
Which two things are used to clinically promote clot dissolution during MI and stroke?
t-PA and Streptokinase
Which factors are measured by PT?
Factors V, VII, X, thrombin and fibrinogen
Which factors are measured by aPTT?
VIII, IX, XI, XII, thrombin and fibrinogen
In aPTT blood is removed from the body and stimulated to clot by _______.
Kaolin, phospholipids and calcium.
In a PT blood is removed from the body and stimulated to clot by the addition of ________.
Thromboplastin and calcium
Which factor is associated with a high molecular weight kininogen (HMWK)? Which pathway is this a part of?
Factor XI - Intrinsic Pathway