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10 Cards in this Set
- Front
- Back
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Cholesterol made?
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Cytosol
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1. Acetyl CoA --> Acetoacetyl CoA
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3-Ketothiolase
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2. Acetoacetyl CoA -->3-hydroxy-3-methylglutaryl CoA (HMG-CoA)
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HMG-CoA Synthase
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HMG-CoA --> Mevalonate
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HMG-CoA reductase
Committed Step Statins are competitive inhibitors |
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Mevalonate-->cholestrol
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Series of steps not shown.
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Is phosphorylated HMG-CoA reductase active/inactive?
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inactive
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Is dephosphoyrlated HMG-CoA reductase active/inactive?
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active
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Insulin
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Dephosphorylates HMG-CoA-->activating
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Glucagon
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Phosphorylates HMG-CoA-->deactivated
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Cholestrol
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Inhibits HMG-CoA reductase synthesis
Favors HMG-CoA reductase degradation |
