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10 Cards in this Set

  • Front
  • Back
Cholesterol made?
Cytosol
1. Acetyl CoA --> Acetoacetyl CoA
3-Ketothiolase
2. Acetoacetyl CoA -->3-hydroxy-3-methylglutaryl CoA (HMG-CoA)
HMG-CoA Synthase
HMG-CoA --> Mevalonate
HMG-CoA reductase
Committed Step
Statins are competitive inhibitors
Mevalonate-->cholestrol
Series of steps not shown.
Is phosphorylated HMG-CoA reductase active/inactive?
inactive
Is dephosphoyrlated HMG-CoA reductase active/inactive?
active
Insulin
Dephosphorylates HMG-CoA-->activating
Glucagon
Phosphorylates HMG-CoA-->deactivated
Cholestrol
Inhibits HMG-CoA reductase synthesis

Favors HMG-CoA reductase degradation