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18 Cards in this Set
- Front
- Back
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FFA is released from TAG and trasferred to blood bound to _____.
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Albumin
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This initiates degradation of TAG to free fatty acids:
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Hormone sensitive Lipase
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Epinephrine and Glucagon ________ hormone sensitive lipase.
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Activate
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Insulin ________ hormone senstive lipase.
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Inactivates
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_________ is required to transport fatty acids from the cytosol to the mitochondria;
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Carnitine
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______ is inhibited by malonyl CoA.
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CPT I
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The first step of beta oxidation is catalyzed by ___________.
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Aceyl CoA Dehydrogenase
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A cAMP cascade has what effect on HSL?
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Phosphorylates it and turns it on.
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What three things work to activate HSL:
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Glucagon, Epinephrine & and NE
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Which two things increase HSL gene transcription?
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Glucocorticoids and Thyroid Hormone
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_________ stimulated beta oxidation of fatty acids by inhibiting phosphodiesterase and allowing it to stay phosphorylated:
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Caffeine
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PKA ________ and acitivates HSL.
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phosphorylates - through cAMP cascade
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How does insulin act to affect HSL?
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It inactivates HSL by activating phosphodiesterase, decreasing PKA and cAMP and dephosphorylating HSL
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Transfers acyl group from CoA to Carnitine:
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CPT I
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Where is CPT I located:
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On the outer surface of the mitochondrial membrane
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Catalyzes the transfer of the acyl group from carnitine to CoA and regenerates free carnitine:
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CPT II
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Coenzyme A must be covalently attached to the carboxylic group of the FA and is catalyzed by which enzyme:
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Aceyl CoA Synthases
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Glucagon and AMPK phosphorylate and inactivate _______, which decreases malonyl coa.
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ACC
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