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15 Cards in this Set
- Front
- Back
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Biosynthesis of ALANINE:
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From PYRUVATE by ALANINE TRASAMINASE.
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Biosynthesis of Aspartate:
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From OXALOACETATE by ASPARTATE TRANSAMINASE
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Biosynthesis of GLUTAMATE:
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SEVERAL WAYS. CARBONS FROM ALPHA KETOGLUTERATE.
(Aminotransfer, glutemate dehydrogenase in reverse) |
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Biosynthesis of GLUTEMINE:
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Made from Glutamate (AKG + NH3 to give GLUTAMINE. glutamine is the primary nitrogen donor.
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Biosynthesis of Asparagine:
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CARBONS FROM OXALOACETATE.
NITROGEN DONOR IS GLUTAMINE. GLN + ASP ---> GLU + ASN |
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Biosynthesis of PROLINE:
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CARBONS FROM ALPHA KETOGLUTERATE.
GLU ---> Glutamate semialdehyde |
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Biosynthesis of Serine:
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CARBONS FROM 3 PHOSPHOGLYCERATE (some from GLY)
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Biosynthesis of GLYCINE:
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Major:
CARBONS FROM Serine (3phosphoglycerate) minor: NH3 + CO2 + THF ---> GLY GLU and choline |
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Biosynthesis of Tyrosine:
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CARBONS FROM PHENYLALANINE (Cofactor- THbiopterin)
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What disorder is associated with high levels of phenylalanine?
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"classical" Phenyketonuria and hyperphenylalanemia.
Liver Phenylalanine hydroxylase system is absent or non-functioning. Causes cognitive impairments. |
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What is "nonclassical" phenylketonuria?
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a result of Tetrahydrobiopterin not being able to be regenerated. treatment with THB.
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What is hyperphenylalaninemia?
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Where tyrosine, tryptophan and phenylalanine cannot be broken down. severely affects cognition. treatment with THB will not work.
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Biosynthesis of CYSTEINE:
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ALL carbons from SERINE (3PG).
make SAM in the process and B12 dependent SAM to Methionine. Also make Homocysteine in the process. |
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Biosynthesis of CYSTEINE:
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ALL carbons from SERINE (3PG).
make SAM in the process and B12 dependent SAM to Methionine. Also make Homocysteine in the process. |
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Biosynthesis of ARGANINE:
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CARBONS FROM ORNITHINE
(requires CARBAMOYL PHOSPHATE) |
