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14 Cards in this Set

  • Front
  • Back
Structure of Amyloidosis
Beta-Pleated sheets
Amyloidosis demonstrated by
Apple-Green Bifringence of Congo red stain under polarized light
Primary Amyloidosis
-Protein
AL
Primary Amylodosis
-Derived from
AL; Ig light chains (multiple myeloma) and B-cel lymphoma Systemic produced by bone marrow
Secondary Amyloidosis
-Protein
AA
Secondary Amyloidoses
-Derived from
Serum amyloid-associated protein (SAA) (chronic inflammatory disease)
Synthesized in liver in response to inflammatory conditions
Secondary Amyloidoses
-What diseases
Acute-phase reactants: rheumatoid arthrithis, renal insufficiency, nephrotic syndrome, restrictive cardiomyopathy
Diabetes Mellitus Type 2
-Protein
Amylin, AE
Senile Cardiac
-Protein
Transythyretin, AF
Medullary carcinoma of the thyroid
-Protein
A-cal (calcitonin)
Alzheimer's disease
-Protein
B-amyloid
Alzheimer's disease
-Protein derived from
Amyloid precursor protein
Dialysis-associated
-Protein
B2-Microglobulin
Dialysis-associated
-Derived from
MHC class I proteins