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9 Cards in this Set
- Front
- Back
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E.coli RNA poly
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inhibited by Rifampin
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Human RNA pol I
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inhibited by alpha-Amanitin
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Human RNA pol II
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inhibited by alpha-Amanitin
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Human RNA pol III
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inhibited by alpha-Amanitin
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Human mitochondrial RNA pol
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inhibited by Rifampin
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Rifampin
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used for mycobacterial infections, in immunosuppressed patients, and tuberculosis
blocks initiation of transcription by binding to beta subunit |
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Rifampin resistance
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point mutation in beta subunit changes rifampin binding site
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Actinomyocin D
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RNA pol inhibitor - binds to the DNA template and interferes with the movement of RNA pol along the strand
phenoxazone ring gets intercalted between two GC pairs |
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Amanita phalloides
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a mushroom that synthesizes alpha-Amanitin
a cyclic octapeptide binds to and inactivates the largest subunit of RNA pol II, RPB1 cell death in gastrointestinal mucosa, liver, and kidneys |
