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24 Cards in this Set
- Front
- Back
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when insulin is around |
it leads to the uptake of glucose we make glycogen |
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when glucagon or epinephrine is around |
glycogen gets degraded and gluconegenisis occurs |
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alpha cells in the pancrease |
detect low blood glucose, secreting glucagon |
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glucagon is a messenger |
from the pancreas... |
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channels allow____ to pass |
ions |
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g coupled receptors |
bind to agonist, activating the g protein, then actives the cell |
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agonist( ligand) leads to
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transport to the nucleus leading than activation of transcription and translation |
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antagonist |
similar to competitive inhibitor |
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all receptors have___ activity |
basal |
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an inverse agonist will lessen |
basal activity |
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antagonist |
no change in activity |
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agonist |
increase in activity ex insulin and glucagon |
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endocrine signaling |
hormones are released in the blood, organs are the target peptide catecholamines thyroid- hormone receptor family:T3, |
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paracrine |
near by ex aCh synaptic vesicles allow sodium and potassium to come in Nicotinic acetylcholine receptor sodium potassium active by nicotine GABA arachidonic acid, pro... |
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autocrine |
self signaling |
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immune syytem |
cytokines chemokines cause cells to move |
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eicosanoids |
prostaglandins-inflammation thromoboxanes leukotrienes |
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cell surface receptors |
tyrosine kinase- growth factor JAK STAT- tyrosine kinase domain Serine-threonine kinase- serine kinase domain- one way phosphorlayted event-smad |
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heptahelical receptors |
a hormone binds to g protein coupled receptor exchanges a GDP for GTP, activation on cell creating a cellular response |
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Ras/MAPK signaling pathway |
contains Grb2 and SOS which binds to Ras |
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ERK 1/2 |
is a mitogen activating protein |
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phosphatidylinositol signaling |
at the 4 & 5 position it is readily phosphoralyted |
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PI3 kinase |
take pip2 and converts in to pip3 |
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insulin binds to receptor causes tyrosine kinase to phosphorylate then goes to |
IRS, |
