Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/14

Click to flip

14 Cards in this Set

  • Front
  • Back
1. OAA ---> Citrate
& regulators
Citrate Synthase
Condensation

Regulated by OAA +
ATP, NADH, Succinyl-CoA (building blocks) -
2. Citrate -->cis-aconitate-->isocitrate
Aconitase
Isomerization
3. Isocitrate ---> Alpha-ketoglutarate
-Isocitrate DH
-Oxidative decarboxylation (lose a carbon dioxide)
-bonuses: NADH, H, CO2
RATE LIMITING STEP
Regulators of rxn 3 Isocitrate DH
ADP is + regulator by decreasing Km for isocitrate

NADH, ATP are - regulators
RATE LIMITING STEP
Regulators of rxn 1 Citrate Synthase
+ OAA levels bc one goal of TCA cycle is to maintain OAA at low levels

- ATP, NADH, succinyl-CoA
4. Alpha-ketoglutarate ---> Succinyl-CoA
-Alpha-Ketogluterate DH
-Oxidative decarboxylation
-RATE LIMITING STEP
-Succinyl-CoA: precursor in heme biosynthesis
-Producde NADH
Regulators of step 4
Alpha-ketoglutarate ---> Succinyl-CoA
NADH & Succinyl CoA are - regulators

RATE LIMITING STEP
5. Succinyl-CoA --->succinate
Succinate thiokinsae
Substrate level phosphorylation
GTP
6. Succinate --> Fumarate
Succinate Dehydrogenase
Oxidation
FADH2
Regulator so Succinate --> Fumarate
FADH2/FAD (-) regulators
Bonus: FADH2 (not NADH bc Succinate not strong enough to reduce NAD)
7. Fumarate --> Malate
Fumarase
Hydration
Bonuses: Malate used in GNG
8. Malate --> Oxaloacetate
Malate Dehydrogenase
Oxidation
Bonuses: NADH
Regulators of step 8, Malate --> OAA
NADH/NAD are negative regulators
Malate --> OAA depends on?
Whether we continue the TCA cycle or send the malate out into the cytoplasm to undergo GNG.

-This reaction has a positive Standard state energy and in order to drive this reaction towards products, we have to keep OAA low.