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6 Cards in this Set
- Front
- Back
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Is this shuttle reversible or irreversible?
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-Reversible
-GNG depends upon the backward movement of this cycle to get malate back into the cytoplasm. |
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Is this shuttle a primary or secondary mechanism of getting electrons into the mitochondria?
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Primary
Heart & liver use this pathway exclusively |
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1. OAA--> Malate in cytosol
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Malate Dehydrogenase in cytosol
Produce NAD |
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2. Malate --> OAA in mitochondria
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Malate Dehydrogenase in mitochondria
Produce NADH |
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3. Transamination rxn in mitochondria
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OAA-->alpha-ketoglutarate as Glutamate -->Aspartate
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4. Transamination reaction in cytosol
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Alpha-ketoglutarate --> OAA as Aspartate -->Glutamate
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