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6 Cards in this Set

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Is this shuttle reversible or irreversible?
-Reversible
-GNG depends upon the backward movement of this cycle to get malate back into the cytoplasm.
Is this shuttle a primary or secondary mechanism of getting electrons into the mitochondria?
Primary
Heart & liver use this pathway exclusively
1. OAA--> Malate in cytosol
Malate Dehydrogenase in cytosol
Produce NAD
2. Malate --> OAA in mitochondria
Malate Dehydrogenase in mitochondria
Produce NADH
3. Transamination rxn in mitochondria
OAA-->alpha-ketoglutarate as Glutamate -->Aspartate
4. Transamination reaction in cytosol
Alpha-ketoglutarate --> OAA as Aspartate -->Glutamate