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10 Cards in this Set

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  • Back
Sickle-cell anemia(hemoglobin S disease)
glutamate (HbA) replaced with valine (HbS)
Hemoglobin C disease
glutamate (HbA) replaced with lysine (HbC)
Hemoglobin SC disease
HbS + HbC
Methemoglobinemia
diminished oxygen-carrying capacity of ferric Hb (MetHb) produces headache, lightheadedness, and dyspnea and cyanosis

Enzyme: NADH cytochrome b5 reductase
alpha thalassemia: Hemoglobin H disease
mild-moderately severe hemolytic anemia
alpha thalassemia:
Hydrops fetalis
all 4 alpha-globin genes defective
alpha thalassemia:
Hb Bart
accumulation of gamma4 tetramers in newborn
alpha thalassemia:
HbH
accumulation of beta4 tetramers in newborn
beta thalassemia:
Major
both beta chains defective
beta thalassemia:
Minor
only one beta chain defective