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10 Cards in this Set
- Front
- Back
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Sickle-cell anemia(hemoglobin S disease)
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glutamate (HbA) replaced with valine (HbS)
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Hemoglobin C disease
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glutamate (HbA) replaced with lysine (HbC)
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Hemoglobin SC disease
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HbS + HbC
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Methemoglobinemia
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diminished oxygen-carrying capacity of ferric Hb (MetHb) produces headache, lightheadedness, and dyspnea and cyanosis
Enzyme: NADH cytochrome b5 reductase |
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alpha thalassemia: Hemoglobin H disease
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mild-moderately severe hemolytic anemia
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alpha thalassemia:
Hydrops fetalis |
all 4 alpha-globin genes defective
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alpha thalassemia:
Hb Bart |
accumulation of gamma4 tetramers in newborn
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alpha thalassemia:
HbH |
accumulation of beta4 tetramers in newborn
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beta thalassemia:
Major |
both beta chains defective
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beta thalassemia:
Minor |
only one beta chain defective
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