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15 Cards in this Set

  • Front
  • Back
What is a sense strand?
The DNA on top...also known as the coding strand
What is the antisense strand?
The DNA on the bottom, also known as the template strand
Can RNA polymerase recognize and correct errors?
NO! But this has less of an impact because MANY copies are RNA are made, where as it's more important in DNA because only one copy is made there
in DNA-directed RNA synthesis, which direction is RNA synthesized from the template?
RNA is synthesized with a 3' to 5' DNA strand as the template, and it synthesizes 5' to 3',, therefore it really goes 3' to 5'
Is a primer needed in RNA synthesis?
what enzyme is needed to initiate and carry out RNA synthesis
RNA polymerase
when rna is created, is it single stranded or double stranded?
single stranded
Is the RNA a copy of the whole dna strand or just part of it?
part of it
What is a promotor?
a specific area on a piece of DNA that is recognizable by the RNA polymerase. this is where transcription begins
explain how RNA transcription is initiated
RNA polymerase combines with omega subunit to recognize the promotor site. Transcription is initiated. Topoisomerases are needed during transcription to prevent supercoiling
Explain the elongation step
RNA polymerase moves in the 5'to 3' direction. After about 10 units are added, the omega subunit dissociates
Explain the termination step
There are two types of termination. There is rho-directed and non-rho directed.

In non-rho directed, it basically terminated by the DNA sequence. In this case, the formation of complimentary bases into a hairpin formation, along with weak AA:UU bonds, the RNA:DNA hybrid dissociates
explain rho dependent termination
the rho factor chases the RNA polymerase down the line. When it hits a hairpin, it stalls. the rho factor catches up and dissociates the RNA
in Euk. cells, transcription is somewhat similar but much more complicated. What is each of the RNA polymerases responsible for?
RNA I--> creates large ribsomal RNA

RNA II--> synthesizes mRNA

RNA II--> synthesizes tRNA/small rRNA
The post transcription process is much more complicated as well. What are the three things that occur to terminate transcription in euk. cells?
5' capping, 3' polyadenylation and splicing