• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/39

Click to flip

39 Cards in this Set

  • Front
  • Back
Which protein is a 7 transmembrane protein
G-protein coupled receptor
The G protein coupled receptor regulates
an enzyme that generates an intracellular second messenger X.
Receptor tyrosine kinase is a receptor that
ligand binding activates tyrosine kinase activity by phosphorylation
Agonists bind to receptors and
promote signaling by the receptor
antagonists bind to receptors and
block agonist binding
antagonists do not elicit a signaling response t/f
True
Signal transduction functions to
activate genes
ligand gated, neurotransmitter gated, nucleotide gated, ion gated, and g protein gated are all types of
ion channels
sodium channels that propogate action potentials and calcium channels at nerve terminals are
voltage gated channels
mechanically gated channels
are a type of ion channel
regulation of channel proteins is accomplished by
covalent modification (activation of cl and ca channels by cAMP dependent phosphorylation
Signal transduction functions to activate genes by
selective opening of ion channels by channel linked receptors
enzymatic activity, ligand stimulated autophosphorylation, activation of a specific G protein
The two main types of gated ion channels are
ligand and voltage gated
ions traveling gated ion channels pass ______their electrochemical gradient
down
extracellular transmitters for regulating ion channel activity are
ACh, g-aminobutyrate, glutamate, glycine
second messengers include
cyclic AMP, IP3, and Cyclic GMP
Cyclic AMP functions to
open channels in olfactory and gustatory cells
IP3 functions to
open calcium channels in ER membrane
Cyclic GMP functions to
keep sodium channels open in rod outer segments
G proteins include Gk, and Go that
open potassium channels in response to activation by various ligands
GABA is
inhibitory
nicotinic ACh receptors form
ligand gated ion channels in plasma membranes
NAChRs are
linked to an ion channel and do not use second messengers
There are ____ subunits for acetylcholine binding
5, (2 alpha, beta, gamma, delta)
in ligand gated ion channels 2 acetylcholine will bind and cause
twisting of M2 helices and polar residues to line the channel
presynaptic neurons contain secretory vesicles containing
acetylcholine
receptor tyrosine kinase activates
tyrosine kinase activity by autophosphorylation
The most common activity found intrinsic to transmembrane receptors is
protein tyrosine kinase activity or PTK
The tyrosine kinase receptor
phosphorylates
classic tyrosine receptors are
monomeric
monomeric receptors can be
1) intracellular-cytoplasmic
2) transmembrane
3) extracellular-ligand
receptor tyrosine kinases have domains rich in
IgG, leucine, cystein, tyrosine, and ligand binding
ligand binding functions are localized to extracellular
aminoterminal domains
cytoplasmic PTK domains are
carboxyterminal
the insulin receptor has ligand binding and PTK on separate _____ linked ppt chains in a _____ complex
disulfide; tetrameric
ligand bound cytokine receptors associate with co-receptors that have separate PTK associated with cytoplasmic domains how?
lightly but non-covalently
Kinases get around an inability to phosphorylate themselves by
ligands bringing them closer together and they phosphorylate eachother
Growth factor induces
receptor dimerization
dimerization results in
receptor autophosphorylation as the two ppt chains phosphorylate each other