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39 Cards in this Set
- Front
- Back
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Which protein is a 7 transmembrane protein
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G-protein coupled receptor
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The G protein coupled receptor regulates
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an enzyme that generates an intracellular second messenger X.
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Receptor tyrosine kinase is a receptor that
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ligand binding activates tyrosine kinase activity by phosphorylation
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Agonists bind to receptors and
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promote signaling by the receptor
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antagonists bind to receptors and
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block agonist binding
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antagonists do not elicit a signaling response t/f
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True
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Signal transduction functions to
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activate genes
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ligand gated, neurotransmitter gated, nucleotide gated, ion gated, and g protein gated are all types of
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ion channels
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sodium channels that propogate action potentials and calcium channels at nerve terminals are
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voltage gated channels
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mechanically gated channels
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are a type of ion channel
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regulation of channel proteins is accomplished by
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covalent modification (activation of cl and ca channels by cAMP dependent phosphorylation
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Signal transduction functions to activate genes by
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selective opening of ion channels by channel linked receptors
enzymatic activity, ligand stimulated autophosphorylation, activation of a specific G protein |
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The two main types of gated ion channels are
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ligand and voltage gated
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ions traveling gated ion channels pass ______their electrochemical gradient
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down
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extracellular transmitters for regulating ion channel activity are
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ACh, g-aminobutyrate, glutamate, glycine
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second messengers include
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cyclic AMP, IP3, and Cyclic GMP
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Cyclic AMP functions to
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open channels in olfactory and gustatory cells
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IP3 functions to
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open calcium channels in ER membrane
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Cyclic GMP functions to
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keep sodium channels open in rod outer segments
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G proteins include Gk, and Go that
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open potassium channels in response to activation by various ligands
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GABA is
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inhibitory
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nicotinic ACh receptors form
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ligand gated ion channels in plasma membranes
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NAChRs are
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linked to an ion channel and do not use second messengers
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There are ____ subunits for acetylcholine binding
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5, (2 alpha, beta, gamma, delta)
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in ligand gated ion channels 2 acetylcholine will bind and cause
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twisting of M2 helices and polar residues to line the channel
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presynaptic neurons contain secretory vesicles containing
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acetylcholine
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receptor tyrosine kinase activates
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tyrosine kinase activity by autophosphorylation
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The most common activity found intrinsic to transmembrane receptors is
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protein tyrosine kinase activity or PTK
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The tyrosine kinase receptor
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phosphorylates
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classic tyrosine receptors are
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monomeric
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monomeric receptors can be
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1) intracellular-cytoplasmic
2) transmembrane 3) extracellular-ligand |
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receptor tyrosine kinases have domains rich in
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IgG, leucine, cystein, tyrosine, and ligand binding
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ligand binding functions are localized to extracellular
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aminoterminal domains
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cytoplasmic PTK domains are
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carboxyterminal
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the insulin receptor has ligand binding and PTK on separate _____ linked ppt chains in a _____ complex
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disulfide; tetrameric
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ligand bound cytokine receptors associate with co-receptors that have separate PTK associated with cytoplasmic domains how?
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lightly but non-covalently
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Kinases get around an inability to phosphorylate themselves by
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ligands bringing them closer together and they phosphorylate eachother
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Growth factor induces
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receptor dimerization
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dimerization results in
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receptor autophosphorylation as the two ppt chains phosphorylate each other
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