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9 Cards in this Set
- Front
- Back
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signal sequence (SS) (4)
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-on polypeptide chain
-13-35 AA residue -located at N-terminus -targets extracytoplasmic (extracellular?)protein |
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signal recognition particle (SRP) (3)
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-protein-nucleic acid complex
-recognizes (binds) a signal sequence (SS) -sends SS's mRNA/ribosomes to the ER |
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signal peptidase (2)
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-in ER lumen
-removes SS |
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SRP receptor
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(signal recognition particle)
-binds SRP-ribosome to ER surface |
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translocon (3)
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-forms pore
-directs growing pp chain across ER membrane -> ER lumen -ATP hydolysis driven |
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phosphoryl grp
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-saccharide attachment site
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PP chain synth (8)
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1. mRNA binds ribosome, protein synth begins
2. SS comes and binds SRP. Syth stops 3. SS-SRP diffuses into ER 4. SRP-SS binds to SRP receptor 5. Ribosome is transfered to the translocon (translocon opens) 6. growing chain threads through translocon into ER lumen 7. Signal peptidase removes SS. Oligosaccharide blocks added in lumen 8. completed pp released into lumen |
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what binds to translocon and what happens on binding
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-ribosome (attached to SS)
-pore opens, allowing pp to ento ER lumen |
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chaperone proteins
(finish 11.2.6) |
-aid protein folding
- - |
