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21 Cards in this Set
- Front
- Back
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Pyruvate -> Acetyl CoA
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Pyruvate dehydrogenase complex
*Inhibited by ATP, NADH (signal high energy state), acetyl CoA (product inhibition) |
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Acetyl CoA + OAA -> Citrate
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Citrate synthase
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Citrate synthase
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Acetyl CoA + OAA -> Citrate
*Inhibited by ATP |
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Citrate <-> cis-Aconitate <-> Isocitrate
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Aconitase
*Susceptible to nitric oxides, can rip out Fe2+ from active site |
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Aconitase
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Citrate <-> cis-Aconitate <-> Isocitrate
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Isocitrate -> alpha-ketoglutarate + CO2 + NADH
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Isocitrate dehydrogenase
*Key regulatory step *Inhibited by ATP, stimulated by ADP |
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Isocitrate dehydrogenase
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Isocitrate -> alpha-ketoglutarate + CO2 + NADH
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alpha-ketoglutarate -> Succinyl CoA + CO2 + NADH
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Alpha-ketoglutarate dehydrogenase
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Alpha-ketoglutarate dehydrogenase
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alpha-ketoglutarate -> Succinyl CoA + CO2 + NADH
*Inhibited by succinyl CoA, NADH |
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Succinyl CoA -> Succinate + GTP
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Succinyl CoA synthase
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Succinyl CoA synthase
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Succinyl CoA -> Succinate + GTP
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Succinate -> Fumarate + FADH2
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Succinate dehydrogenase
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Succinate dehydrogenase
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Succinate -> Fumarate + FADH2
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Fumarate + H2O -> Malate
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Fumarase
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Fumarase
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Fumarate + H2O -> Malate
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Malate -> OAA + NADH
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Malate dehydrogenase
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How many of the following are formed in the TCA cycle:
NADH: ? FADH2: ? GTP: ? CO2: ? |
NADH: 3
FADH2: 1 GTP: 1 CO2: 2 |
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During what step(s) is NADH formed?
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Isocitrate -> alpha-ketoglutarate
Alpha-ketoglutarate -> Succinyl CoA Malate -> OAA |
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During what step is GTP formed?
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Succinyl CoA -> Succinate
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During what step is FADH2 formed?
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Succinate -> Fumarate
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During what step(s) is CO2 formed?
Hint: Same as NADH |
Isocitrate -> alpha-ketoglutarate
Alpha-ketoglutarate -> Succinyl CoA |
