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10 Cards in this Set

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catalyzes the oxidation of Pyruvate to acetyl CoA there by providing a link b/t Glycolysis and TCA cycle. It is regulated by ATP demand.
PDH Complex
Brain is entirely dependent on the oxidation of ? to fulfill its ATP needs, and regulation of PDH complex is a life and death matter.
Glucose
Glycolysis takes place in the?
Pyruvate Decarboxylase and the Krebs cycle takes place within?
Aqueous Cytoplasm
matrix of the mitochondrion
glucose is converted to pyruvate by glycolysis, then completely gets oxidized by CO2 following this pathway?
PDH complex
In cells/tissues w/ high energy charge, pyruvate is directed towards?
when charge is low?
Gluconeogenesis

Pyruvate is preferentially oxidized to CO2 and H2O in the TCA cycle, w/generation of 15 equivalents of ATP/pyruvate.
central compund in metabolism in mitochondria.
Acetyl CoA, product of the Pyruvate Dehydrogenase rxn.

High Energy thioester linkage makes it an excellent donor of the acetate moiety.
the bulk of ATP used by many cells to maintain homeostasis is produced by the?
oxidation of pyruvate in the TCA cycle.

generates NADH and FADH2
PDH Complex Enzymes? (3)
Pyruvate Dehydrogenase
Dihydrolipoyltransacetylase
dihydrolipoyldehydrogenase
PDH complex coenzy's?(5)
TPP
Lipoic Acid
Fad+
CoA
NAD+
Nutritional Deficiency of thiamine leads to the disease?
Beriberi