Biochem - T3 - Pdh Complex

Front 1

catalyzes the oxidation of Pyruvate to acetyl CoA there by providing a link b/t Glycolysis and TCA cycle. It is regulated by ATP demand.

Back 1

PDH Complex

Front 2

Brain is entirely dependent on the oxidation of ? to fulfill its ATP needs, and regulation of PDH complex is a life and death matter.

Back 2

Glucose

Front 3

Glycolysis takes place in the?
Pyruvate Decarboxylase and the Krebs cycle takes place within?

Back 3

Aqueous Cytoplasm
matrix of the mitochondrion

Front 4

glucose is converted to pyruvate by glycolysis, then completely gets oxidized by CO2 following this pathway?

Back 4

PDH complex

Front 5

In cells/tissues w/ high energy charge, pyruvate is directed towards?
when charge is low?

Back 5

Gluconeogenesis

Pyruvate is preferentially oxidized to CO2 and H2O in the TCA cycle, w/generation of 15 equivalents of ATP/pyruvate.

Front 6

central compund in metabolism in mitochondria.

Back 6

Acetyl CoA, product of the Pyruvate Dehydrogenase rxn.

High Energy thioester linkage makes it an excellent donor of the acetate moiety.

Front 7

the bulk of ATP used by many cells to maintain homeostasis is produced by the?

Back 7

oxidation of pyruvate in the TCA cycle.

generates NADH and FADH2

Front 8

PDH Complex Enzymes? (3)

Back 8

Pyruvate Dehydrogenase
Dihydrolipoyltransacetylase
dihydrolipoyldehydrogenase

Front 9

PDH complex coenzy's?(5)

Back 9

TPP
Lipoic Acid
Fad+
CoA
NAD+

Front 10

Nutritional Deficiency of thiamine leads to the disease?

Back 10

Beriberi