Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
24 Cards in this Set
- Front
- Back
|
What are the 3 central enzymes for non-essential amino acids?
|
glutamate DHSE, glutamine synthestase, and aminotransferase
|
|
|
glutamate is synthesized via what enzyme?
|
glutamate DHSE
|
|
|
gluatmamine is synthesized from what?
|
glu-glu synthetase
|
|
|
Alanine is sythesized via?
|
transamination of pyruvate
|
|
|
aspartate is synthesized via?
|
transamination of OAA
|
|
|
Tyrosine is synthsized via?
|
hydroxylation of phenylalanine
|
|
|
what is the mechanism of synthesis of bases?
|
feedback mechanisms
|
|
|
Pyrimidine nucleotides are formed via?
|
ribose 5 p added after ring formation of a base
|
|
|
What is the prosthetic group intially formed when making pyrimidine nucleotides?
|
UMP
|
|
|
What forms the ring for pyrimidine nucleotides
|
aspartate and carbamoyl-P
|
|
|
What are the 3 main differences btwn. carbamoyl-P synthesthase 1 and 2?
|
cytosolic location
uses glutamine not NH4+ not allosterically regulated by N-acetylglutamate |
|
|
what is the name of the enzyme for the committed step in synthesis of UMP?
|
aspartate transcarbamolyase
|
|
|
How is the ribose-5-P formed for synthesis of UMP?
|
from phosphoribosyl-PPi
|
|
|
What is the enzyme responsible for the following rxn.s?
UMP + ATP -> UDP + ADP UDP + ATP -> UTP + ADP? |
nucleoside-P kinase
|
|
|
to make a purine nucleotide, what must you start with?
|
ribose-5-P, then ring formation of the base
|
|
|
deoxyribonucleotidesw acts only at what level?
|
diphosphate
|
|
|
what is the enzyme for deoxyribonucleotides?
|
ribonucleotide reductase
|
|
|
What are the 2 things required for deoxyribonucleotide? n
|
NADPH and a peptided coenzyme: thioredoxinn (-SH)
|
|
|
What enzyme catalyzes the following rxn?
dUMP -> dTMP (FH4)? |
thymidylate synthase
|
|
|
what enzyme regenerates FH4 to FH2?
|
dihydrofolate reductase
|
|
|
Methotrexate and aminopterin decrease
|
DNA synthesis
|
|
|
Fluorouracil -> 5 dUMP- suicidally inhibits?
|
thymidylatge synthase
|
|
|
during purine catabolism, both G and A are converted into?
|
xantihine
|
|
|
allopurinol is an inhibitor of ?
|
xanthine oxidase
|
