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13 Cards in this Set
- Front
- Back
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Where are steroid hormones synthesized: Glucocorticoids and mineralcorticoids?
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Adrenal cortex and gonads
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Where are steroid hormones synthesized: Androgens?
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Leydig cells (testes), adrenal cortex, and ovary
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Where are steroid hormones synthesized: Estrogens?
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Granulosa cells (ovary)
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Where are steroid hormones synthesized: Progestins?
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Corpus Luteum
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What is the rate determining step in steroid hormone synthesis?
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Cholesterol-->Pregnenolone (catalyzed by P450scc) (SIDE CHAIN CLEAVAGE)
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Describe the general mechanism for steroid hormones. Start with hormone in the blood and end with gene transcription.
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-Hormone in the blood, bound to albumin (or a specific carrier)
-Passively diffuses across cell membrane -Bind to specific receptors in cytoplasm/nucleus -Bound receptors bind to DNA to regulate gene transcription |
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How many carbons does cholesterol have?
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27
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What is the precursor for mineralcorticoid and glucocorticoid synthesis? What is the primary glucocorticoid in the body? What is the primary mineralcorticoid in the body?
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-Progesterone
-Cortisol -Aldosterone |
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Where is N1 from in purine?
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-aspartic acid
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How do you number the atoms in a purine ring?
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Start at N1, go counter clockwise around the 6 atom ring to get to N3. Then go clockwise around 5 atom ring, starting at top.
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Where is C2 from in purine?
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-tetrahydrafolate
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Where is N3 from in purine?
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-glutamine
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Where is C4, C5, N7 from in purine?
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-glycine
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