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13 Cards in this Set
- Front
- Back
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Tophi
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accumulation of crystal aggregates in soft tissue
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uric acid has a pka of?
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5.7, only in part of urinary tract where pH is less than 5.7 is uric acid found
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more common in men or women?
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more common in men(by 5 times)
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Hyperuricemia needs how many mg/dl in men vs women
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men 7 mg/dl need less than this
women 6mg/dl |
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podagra
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gout effecting great toe
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what cells are recruited to urate crystals?
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neutrophils, chemotactic to proteins on urate crystals, eat them and are lysed
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urolithiasis
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uric acid stones seen at chronic tophaceous gout stage
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Primary gout
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decreased excretion, idiopathic(unknown),
defects increase PRPP - super synthetase X linked, makes PRPP from R-5-P - HGPRT quasi deficiency |
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Secondary gout
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gout is subordinate manifestation of an unferlying disorder
total deficiency of HGPRT - lesch nyhan increased cell turnover - cancer etc alcohol - increase ATP to AMP |
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two ways to degrade AMP
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AMP -> IMP -> insosine -> HX
AMPdeaminase nucleotidase PNP or AMP-> adenosine -> inosine ->HX nucleotidase, ADA , PNP |
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Antiinflammatory agents for gout
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colchicine - depoles MT's to inhibit neutrophil phago, causes diahhrea naseau vomiting
corticosteroids non-steroidal agents NSAID's -indomethacin, NOT ASPIRIN, competes with urate for excretion GI bleeding |
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Uricosuric Agents
properties ex |
increase renal excretion, inhibit proximal tubular reabsorption of urate
Probenecidad |
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what are the small bumps found near the ear?
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tophi, urate crystal accumulation in soft tissue
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