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20 Cards in this Set
- Front
- Back
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what kind of bond forms between the 5' phosphate and 3'OH when making DNA?
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ester
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Prok POL I
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monomeric
5'-3' elongation 3'5' exonuclease proofreading 5'3' exonuclease primer removal |
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prok POL III
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heteromeric
5'3' elongation 3'5' proof reading exonuc |
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what is DNA G in the primosome?
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primase, generates primers
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How do you terminate replication
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replication forks meet at ter seq's which bind proteins that inhibit DNAB (helicase)
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Euk POL alpha
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nuclear localization
initiation 5'3' polymerase |
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EUK pol beta
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repair
5'3' polymerase |
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EUK pol delta
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main
elongation 5'3'polymerase 3'5'exonuclease |
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EUK pol epsilon
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repair
5'3'polymerase 3'5'exonuclease |
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EUK pol gamma
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mitochondria
replication |
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RNAase H
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primer removal, 5'3' exonuc
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alkylating agents, deaminants (NaNO3),
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cause damage to DNA
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UvrA
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ATP binding zinc finger helix turn helix, helicase subunit
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UvrB
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ATP binding
3'nuclease helicase subunit |
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UvrC
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5' nuclease
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UvrD
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displaces fragment
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Base excision repair
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DNA glycosylase removes base
apyrimidinic endonuclease and exonuclease cuts AP site |
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HNPCC hereditary nonpolyposis colorectal cancer
inheritance defect in |
AD
mismatch repair defect |
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XP
inheritance defect in |
AR
defect in UV-induced thymine dimer repair |
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no human analog for mut l s or h?
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mutH
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