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20 Cards in this Set

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  • Back
what kind of bond forms between the 5' phosphate and 3'OH when making DNA?
ester
Prok POL I
monomeric
5'-3' elongation
3'5' exonuclease proofreading
5'3' exonuclease primer removal
prok POL III
heteromeric
5'3' elongation 3'5' proof reading exonuc
what is DNA G in the primosome?
primase, generates primers
How do you terminate replication
replication forks meet at ter seq's which bind proteins that inhibit DNAB (helicase)
Euk POL alpha
nuclear localization
initiation
5'3' polymerase
EUK pol beta
repair
5'3' polymerase
EUK pol delta
main
elongation
5'3'polymerase
3'5'exonuclease
EUK pol epsilon
repair
5'3'polymerase
3'5'exonuclease
EUK pol gamma
mitochondria
replication
RNAase H
primer removal, 5'3' exonuc
alkylating agents, deaminants (NaNO3),
cause damage to DNA
UvrA
ATP binding zinc finger helix turn helix, helicase subunit
UvrB
ATP binding
3'nuclease
helicase subunit
UvrC
5' nuclease
UvrD
displaces fragment
Base excision repair
DNA glycosylase removes base
apyrimidinic endonuclease and exonuclease cuts AP site
HNPCC hereditary nonpolyposis colorectal cancer
inheritance
defect in
AD
mismatch repair defect
XP
inheritance
defect in
AR
defect in UV-induced thymine dimer repair
no human analog for mut l s or h?
mutH