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26 Cards in this Set
- Front
- Back
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first step in deoxyribonucleotide synthesis
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structure of ribonucleotide reductase
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Ribonucleotide reduction mechanism
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what do the different sites of ribonucleotide reductase do, and what substrates do they take?
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how is Vmax changed in ribonucleotide reductase?
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Draw out the complex effects which surround the specificity site of ribonucletotide reductase
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draw out the two pathways that get electrons to ribonucleotide reductase (RNR)
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alternate role of Thioredoxin, rather than in the creation of dNDPs
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where does dTMP come from? and what is it called?
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comes from either CDP or UDP
is called Thymidylate |
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why don't cells use dUTP to make dTTP directly?
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the body doesn't want to accumulate dUTP because it doesn't want it to be introduced into DNA
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what happens to THF when methylating dUMP?
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how to get back to THF from 7,8-dihydrofolate (after putting methyl group on dUMP)
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what does methotrexate do for cancer therapy?
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it is an analog of DHF, inhibits dihydrofolate reductase
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what drug is an analog of DHF and inhibits dihydrofolate reductase?
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methotrexate
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what does 5-fluorouracil do for cancer therapy?
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creats fdUMP, which is an analog of dUMP, inhibits thymidylate synthase
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what is an analog of dUMP, and inhibits thymidylate synthase?
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5-fluorouracil, which turns into FdUMP
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how is azaserine (O-diazoacetyl-L-serine) used in cancer therapy?
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analog of Gln, inhibits glutamine amidotransferases (steps 1&4 of purine biosynthesis, CTP synthetase, & carbamoylphosphate synthetase II)
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what is an analog of Gln. Inhibits Gln amidotransferases (steps 1&4 of purine biosynthesis, CTP synthetase, and carbamoylphosphate synthetase II)
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azaserine
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how are purines broken down in primates?
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draw out the formation of uric acid from purines
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nucleotide cause of Severe combined Immunodeficiency Disease (SCID)
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cause and solution to gout
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regenerating nucleotides form free purine and pyrimidine bases
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symptoms of Lesch-Nyhan syndrome
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intellectual disability
self-mutilation cerebral palsy elevated uric acid |
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what causes:
intellectual disability self-mutilation cerebral palsy elevated uric acid? |
lesch-nyhan syndrome
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how to tell prenatally if Lesch-Nyhan Syndrome is present
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no conversion occurs between IMP to hypoxanthine
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