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5 Cards in this Set

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Where can Fatty Acids come from?
Fatty Acids come from 3 sources: Diet, Adipocytes, De novo synthesis
What problems arise when mobilizing fatty acid-containing metabolites? How is this dealt with?
Problem:Insolubility
Solution: hormones trigger breakdown of triglycerides and the release of FA in to the blood from ADIPOCYTES where Albumin is used to carrier lipids
Detergents (Cholic and Deoxycholic acid) emulsify DIETARY triacylglycerols which is broken down. Then resynthesized and transported in chylomicrons by the lymphatic system.

???stored in seperate cells, degraded in the mitochondria and synthesized in the cytosol, Chylomicron
Where can Fatty Acids come from?
Fatty Acids come from 3 sources: Diet, Adipocytes, De novo synthesis
What problems arise when mobilizing fatty acid-containing metabolites? How is this dealt with?
Problem:Insolubility
Solution: hormones trigger breakdown of triglycerides and the release of FA in to the blood from ADIPOCYTES where Albumin is used to carrier lipids
Detergents (Cholic and Deoxycholic acid) emulsify DIETARY triacylglycerols which is broken down. Then resynthesized and transported in chylomicrons by the lymphatic system.

???stored in seperate cells, degraded in the mitochondria and synthesized in the cytosol, Chylomicron
How are fatty acids activated as acyl-CoA derivatives? Why?
acyl-CoA synthetase or acyl-CoA ligase catalyzes the formation the thiol ester bond between the FA and CoA makes the alpha proton relatively acidic. This is done because the extraction of an alpha is an important step in B oxidation