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22 Cards in this Set
- Front
- Back
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which AA are modified by the GA
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serine
threonine asparagine |
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what enzyme matches AA to tRNA
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amino acyl tRNA synthetase
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which antibiotics inhibit 50s
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chloremphenical
clindamycin erythromycin lincomycin linezolid streptogramins macrolides |
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which antibiotics inhibit 30s
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aminoglycosides
tetracyclines |
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clinical features of osteogenesis imperfecta
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blue sclera
dental problems bone fractures hearing loss |
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where does aminoacyl tRNA synthetase work
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3' hydroxy
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what happens to a mischarged tRNA
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reads usual codon but inserts wrong AA
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where are ribosomes made
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nucleus
then transported out to the cytoplasm |
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what inhibits aminoacyl tRNA
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tetracyclines
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what inhibits peptidyltransferase
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chloremphenical
streptogramins |
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what blocks translocation
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macrolides
clindamycin linezolid |
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what catalyzes peptide bond formation
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ribosomal rRNA
ribozyme peptidyltransferase |
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what causes translocation in eukaryotes
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EF-2
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what causes translocation in prokaryotes
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EF-G
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what causes initiation
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GTP hydolysis
eIF help assemble 40s |
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what are the post-translational modifications
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trimming
-removal of N or C terminal covalent alterations -phosphorylation -glycosylation -hydroxylation proteasomal degradation -ubiquitin -lysosomal degradation -Ca dep enzymes |
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what does type 1 collagen make
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bone
skin tendon cornea |
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what does type 2 collagen make
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cartilage
vitreous body nucleus palposus |
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what does type 3 collagen make
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blood vessels
uterus fetal tissue granulation tissue |
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what does type 4 collagen make
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basement membrane
basal lamina |
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what makes elastin so resiliant
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extensive desmosome cross linking
accomplished by lysyl hydroxylase |
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what AA is elastin abundant in
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proline and glycine
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