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39 Cards in this Set
- Front
- Back
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alpha 1
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vasoconstriction
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alpha 2
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inhibit SNS, inhibit insulin release
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beta 1
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increase heart rate, contractility, renin release, acqueous humor formation, lipolysis
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beta 2
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vasodilation, bronchodilation, increase glucagon release
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M1
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CNS
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M2
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heart decrease
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M3
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exocrine glands increase
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D1
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renal vasodilation
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D2
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modulate transmitter release in brain
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H1
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pruritus, pain, bronchoconstriction, increase mucus production
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Type I Collagen
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bone, tendon, skin, fascia, cornea, late wound repain, dentin
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Type II Collagen
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Cartilage, nucleus pulposus, vitreos body
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Type III
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skin, blood vessels, uterus, fetal tissue, granulation tissue
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Type IV
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basal lamina, basemnet membrane
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Type X
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epiphyseal plates
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Collagen formation
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hydroxylation of lysine, proline in ER
glycoslyation of lysine in Golgi; triplex procollagen formed adn released into ECM Ends cleaved to insoluble tropocollagen; fibril formation with lyslyl oxidase to stablize alpha chain triplets |
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Primary sequence of colalgen
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glycine-X-Y; X - proline, Y hydroxyproline or hydroxylysine
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Ehlers Danlos
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defect in lysly oxidase, cannot form cross links;
extensible skin, mobile joint, easy bruising Inheritance variable, 10 types; associated with berry aneurysm |
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Scurvy
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Vit C deficieny
defect in hydroxylation of lysine bleeding gums, easy bruising |
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Osteogenesis imperfecta
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AD (DOsteo)
Bone fractures, blue sclerae, loss of hearing, lack, of dentition (eye, ear, mouth, skull) Defect in glycosylation of chain Type II - fatal in utero or neonatal Incidence 1:10 000 |
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ATP 2 phosphoanhydride bonds
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7 kcal/mol each
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Aerobic metabolism via malate shuttle
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38 ATP
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Aerobic metabolism via G3P shuttle
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36 ATP
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Anaerobic metabolism
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2 ATP
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Phosphory
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ATP
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Electrons
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NAD, FAD, NADPH
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Acyl
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coenzyme A, lipoamide
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CO2
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biotin
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1 carbon units
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THF
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CH3
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SAM
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aldehyde
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TPP
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glucose
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UDP
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Choline
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UDP
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Glutamate
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GABA
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Fructose 6 Phosphate
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Fructose 1,6 bis P (via PFK)
rate limiting enzyme of glycolysis |
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Pyruvate - Oxaloacetate
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pyruvate decarboxylase
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Oxaloacetate - PEP
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PEP carboxykinase
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F1,6BP - F6P
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F16BPase
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G6P - Glucose
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G6Pase
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