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46 Cards in this Set

  • Front
  • Back

what is a trace element and function as cofactor for enzymes

selenium

glutathione peroxidase GPx


iodothyronine deidinase IDI

selenium

what are the symptoms in Se deficiency in animal

white muscle disease in sheep


unsteady gate and arched back

deficiency in human

in some area in china- keshan diease- enlargement of heart, loss of flexibility (cardiomyopathy)


- low Se content in soils

is there Se deficiency disease in here?


does it particially assocaited with cancer

no


yes

explain the fuction of selenium

free radical attack, fatty acid peroxides cause damage,


so GSH + Se to GSSG to fatty alcohols then harmless catabolism



GPx helps arrest lipid peroxidation

what are the other function of selenium

IDI is controls the thyroid funciton, T4 to T3


thioredoxin reductase


25 selenoproteins in mammals

zinc deficiency

- stunted growth i children


- decreased taste sensation


- imparied imune funcion


severe deficiency

- dwrfism


- delayed sexual maturation


- hypopigmented hair

human in zinc deficiency first reported in egypt

diets low in meat, staple based on beans, unleaved bread, other wholegrain foods, high in fibre and ohytate

causes of zinc deficiency

- decreased intake, absorption or increase intake of inhibitor


- increased losses - votmit, poo



increased- requirement- growth, pregnancy, lactation

zinc intake enhancers

animal protein


organic acids

zinc inhibitors

phytate


calcium


iron copper


oxylate (spinitch, chocolate)

zinc intake requirement: 8, 18


hre: 15.2, 10.2

sufficient

food rich in zinc

oysters


red meat


chickn thigh


sole

what are functions of zinc

regulation


protein and nucleic acid metabolism


lipid and carb metabolism


interactions with hormones


growth and reproducton


immune function T cells


appetite- taste acuity,night vision


vitamin A metabolism

RDI for zinc


n intake

60-70


30-60

good source for selenium

high:


fish, brazil nuts, liver and kidney



medium


poultry/eggs, other meat


history of goitre


post-re-emergence of mild iodine deficiency

iodine

mild and moderate ID

smaller than


100


50

reasons for reduction in iodine status

- reduction in use idophors in dairy industry


- lower intake of iodised salt


- decreased use of discretionary (salt)


- use of non-iodised forms: rock salt

what are some IDD?

hypothyroidism <100


goiter <50


imparied mental function <50


retarded physical develpment and


abortion stillbirths, congenital abnormalities <25


cretinism <25

mandatory iodine fortification

iodine salt in bread

what deficiency is most common around the world

roni

shuttle between ferrous to ferric forms


also assist many enymes

iron

RDI for iron

8, 18


1% males and 26% females have inadequate intakes

what are the supply for iron

- amount eaten


haem vs non haem


promoters andinhibitors in diet

what are the requirements of iron

absortion higher if sttus low


menstration


growth, regnancy an lactation


presence of infections

animal flesh


from plants

- provide haem and non-haem


- non haem

intake of haem and non haem

10-15 non- 85-90

of absorption

haem: 25-35 non- haem: 2-10

ron promoters and inhibitors

promoters:


vitamin C


meat fish an protein taken at the same time as non-heme iron



inhibitors


phytates


coffee and tea


EDTA


calcium, vinc and manganese

absorption higher if status low

cool


during life when you are pregnant or groth spurt you need iron

iron deficiency severe

low stores and anaemic

functions of vitamin A

- functio in vision


- integrity of epithelial cells


- embryonic development


- maintnace of immune function


what is vitamin A deficiency called

xerophthalmia

what are the components and process of itamin A formation cis- trans

opsin and 11-cis retinal= rhodopsin


change in shape leads ot nerves impulse

two types of vitamin A

preformed retinol


provitamin A carotenoids

beta carotene


dioxygenase- 2 retinols


yeah


vitamin D process

7 dehydrocholesterl


D3


dietary intake (both to liver)


25 D3


to kidneys


form 1,25 dihydroxyvitamin D3



this maintain calcium balance in the body

vitamin D deficiency in adults and chldren?

osteomalacia


ricket

people with fat malabsorption

also leads to deficiency, risky

source for vitamin D

oily fish and egg yolk


mushrooms that is exposed to the sun



and vitamin D is permitted to be added to diary product



analogues derived fromlegumes and cereals


have you have too much

yes, hypercalcaemia

main source from vitamin E (tocopherol)

oil from plants and animal food- fatty tissues


and the function is maintaencance of membrne integrity


deficiency is rare

what does part of coensyme thaimin pyrophosphate does

assist in energy metabolism of all cells


situated on the membrane o nerve cells


rapid turn over limited storage.