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47 Cards in this Set
- Front
- Back
HM had what removed
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medial temporal , including hippocmpus and amydala
from BOTH sides |
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HM can retain
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normal amount of info, if not distracted
slightly higher IQ |
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ischemia
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reduced blood to brain, can produce similar symptoms of HM
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patient NA suffered damage to
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dorsomedial thalamus, both mammilaries
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NA suffers
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amnesic for verbal learning, moslty anterograde
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Both NA and HM
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normal ST, impaired LT< preserved ablility to form non declarative memories
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korsakoff & brain
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dorsomedial thalamus
mammilary bodies frontal ctx not temporal lobe |
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KC & brain damage
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left frontal parietal
left parietal occipital reduced hippocampus |
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KC & memory
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loss episodic, semantic OK
deficits due to cortical damage, particluarly FRONTAL PARIETAL |
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sensitization
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if there is a sudden increase in strength in stim that has not been habituated, subsequent reactions exaggerated
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three reasons for loss of memory
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never formed
deteriorates as consequence of time may be irretrievable from injury |
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iconic memory
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a few seconds at most
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two alternative, forced choice procedure
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present 1000
correct recognize 90%, even with 10,000 to discriminate from |
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delay non match to sample
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medial temporal lobe impairs declarative memory
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animal research has shown that _ is unimportant in declarative memories
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amygdala
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kesner's experiemnts limited to
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short term memory
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test phase of kesner rat study
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food in arm that the rats just entered
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lesions in X impair 8 arm maze task, test phase
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hippocampus
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response task of kesner
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rienforce if turns SAME direction, memory of previous response
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lesions of X impair kesner's response task
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cuadate nucleus
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kesner sensory task & brain region
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must go to novel object, nock over object not yet seen
lesions to extrastriate visual ctx |
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kesner tests reveal X of three brain regions
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dissociation
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dorsal striatum
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important for nondeclarative memory
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right hippocampus and para hippocampal gyrus
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spatial stimuli
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left hippocampus and parahippocampal gyrus
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verbal stimuli
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encoding episodic info depends on X portion of medial temporal
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rostal
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retrieval of episodic info depends on X portion of medial temporal
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caudal
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when listening to autobiographical passage, increase activation of
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right frontal and temporal lobesstu
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study of Drosophilia demonstrated X type learning
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nonassociative
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dorsolateral prefrontal system
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required for object perminance
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conditioning does / does not modify the simple arc reflex
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does change
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cell assembly
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laterations in pattern of firing can encode meories
each neurons in ensemble may participate to greater or lesser extent signature of activity pattern for each stored item |
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hebbian synapses, & continual firing
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if close enough to continue to increase firing, then METABOLIC or STRUCTURAL changes in one or both take place to increase EFFICACY
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fire together wire together
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simultaneous firing
conditional learning |
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hebb & dual trace hypothesis
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experience sets up activaiton of neural circuit that reverberates
hold for short period if activation sufficient, activity in circuit causes a stable change stable change corresponds to memory trace |
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in EC IC, EC animals exhibited
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increase number of dendritic spines, particularly on basal dendrites
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filopodia
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electrical activity of neurons promotes these dendritic extensions
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how do filopodia form dendritic spine?
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contact axon, activation of AMPA or NMDA receptors stabilizes
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main inputs to hippocampal formation come from
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entohinal ctx
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main input to hippocamap formation come from entohinal ctx via
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perforant pathway
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drugs thata inhibit CaM kinase interfere with..
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intermediate memory
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long term depression LTP
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lasting decrease in magnitude of response of neurons after afferent cells have been activated with electrical stimuli of low frequency
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amnestics
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drugs that cause memory failure
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FOXP2
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mutation - long lasting difficulty w/ language
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broca's patient exact location
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inferior frontal left hemesphere
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electrical stimulation of this part of brain results in speech arrest
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anterior region
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planum temporale
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involved in language
asymmetrical |