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8 Cards in this Set
- Front
- Back
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describe and give examples of ligand-gated ion channel receptors
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Several subunits span the membrane
effect is to open an ion pathway very fast response , ms Examples: AcH, Glutamate, GABA |
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G-protein coupled receptors
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1-2 dissimilar subunits span the membrane
interact with effector molecule via G-protein response time = seconds Ex. Beta-adrenergic, PARs B-receptor has 7span shape. |
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Insulin-like receptors
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2 A and B subunits transmembrane
phosphorylate themselves, attaching P to tyrosine Ex. Insulin receptor, growth factors response time = minutes |
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intracellular receptors
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reside in the nucleus, response time = hours, change gene expression
i.e. receptors for steroids, vitamin D, retionids, thyroid hormones |
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List the major 4 types of receptors
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ligand-gated ion, g-protein, intracellular, and insulin-like
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what physical charactertistics distinguish the groups of receptors from each other?
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intracellular = inside nucleus
other 3 = cell membrane ligand-gated = 5 similar subunits insulin-like = phosphorylate themselves G-protein = special PAR receptor that has a 7-span shape |
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how do g-protein coupled receptors accomplish their cellular effects
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activated after being bound by a hormone where they then affect cAMP and cGMP and cause an effect on an effector molecule
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what is PAR
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Protease Activated Receptors are G-protein linked receptors that are activated by the proteolytic removal of a portion of the N-terminus of the 7span shaped receptor by thrombin or trypsin.
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