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5 Cards in this Set
- Front
- Back
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The major noncarbohydrate precursors are: |
lactate, amino acids, and glycerol |
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Three irreversible glycolysis reactions |
hexokinase, phosphofructokinase, pyruvate kinase |
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The two main reasons why gluceogenisis is not reversible from glycolysis |
1. The delta g free energy of glycolysis is -74 kj/mol If gluconeogenesis were just the reverse of glycolysis, its ΔG would be positive
2. Reciprocal regulation of glycolysis and gluconeogenesis:When glycolysis is active, gluconeogenesis is turned off, and when gluconeogenesis is proceeding, glycolysis is turned off. |
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inhibits glycolysis when gluconeogenesis is active, and vise versa |
reciprical control |
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Three steps replaced in gluceogenisis |
(Pyruvate Carboxylase) and (PEP carboxykinase) replace the pyruvate kinase reaction of glycolysis(Fructose-1,6-bisphosphatase) replaces the phosphofructokinase reaction of glycolysis(Glucose-6-phosphatase) replaces the hexokinase reaction of glycolysis the new reactions provide for a spontaneous pathway (DG negative in the direction of sugar synthesis), and they provide new mechanisms of regulation |
