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13 Cards in this Set
- Front
- Back
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What else can cause disorders even if all chromosomes are present in normal numbers?
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Abnormalities in structure and breakage of a chromosome
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What is happening if a fragment of a chromosome is lost?
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Deletion
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If a fragment reattaches to the original chromosome but in the reverse direction, what results?
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Inversion
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If a fragment of a chromosome is lost, what will it produce there?
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Duplication
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What is the attachment of a chromosomal fragment to a nonhomologous chromosome?
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Translocation
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Which are the least likely to produce harmful effects?
(Deletion, Duplication, Inverse, Translocation) |
Inversion
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Which is the most likely to produce harmful effects?
(Deletion, Duplication, Inverse, Translocation) |
Deletion
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What is cri du chat?
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A special deletion in chromosome 5 which causes mental retardation and the suffer to mew like a cat. It almost always causes death in infancy.
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What do chromosomal changes in a sperm or egg cell cause?
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Congenital disorders
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What do chromosomal changes in a somatic cell cause?
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Development of cancer
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Which is usually related to cancer, CML and leukemia?
(Deletion, Duplication, Inverse, Translocation) |
Translocation
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Why is cancer not usually inherited?
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Because the chromosomal changes in cancer are usually confined to somatic cells
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What happens in CML cells?
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A part of chromosome 22 has switched places with a small fragment from chromosome 9. This activates a gene that leads to leukemia.
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