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4 Cards in this Set
- Front
- Back
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Im = Ir + Ic; under voltage clamp, why is all current ionic?
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since voltage is not change, Ic = 0
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What does a suprathreshold depolarizing current produce in voltage clamp study?
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brief capacitative current (as Vm changes from -65mV to 0mV; numbers may vary)
gating current (tiny current associated with initial opening of channels) transient inward current (counteract Na+ influx) delayed outward current (counteract K+ efflux) |
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How can you experimentally prove if an ion is causing a specific current?
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modify Ena by changing EC [Na] and see if this changes the current
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how can we estimate density of Na channels?
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using radiolabelled STX or TTX
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