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14 Cards in this Set
- Front
- Back
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What hormone do hypophysectomized animals lack? What is the effect?
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ACTH. Deficits in learning a shock-avoidance response
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What effect does atropine have on learning and behavior?
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Dissociation between behavior and state of consciousness. Impairs learning.
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What effect does serotonin have on learning?
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Increased pain sensitivity menas faster acquisition of avoidance response.
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What roles do alpha and beta norepinephrine receptors have?
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Alpha - hungry
Beta - feel satiated |
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How does strychnine affect learning?
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inhibits inhibitory neruotransmission, facilitating the learning of some tasks.
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How does amphetamine affect learning?
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Promotes release of DA and NE and inhibits their uptake by presynaptic neurons. Enhance attention.
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What do cycloheximide and anisomycin do?
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They are protein synthesis inhibitors that produce amnesia and impaired retention of a task learned previously.
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What are two ways in which the perceived effects of drugs are assessed?
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1. Drug discrimination
2. State-dependent learning |
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What factors are important for a drug's effects on stimulus control?
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1. Drugs must act centrally
2. Sensory stimuli may be perceived differently under influence of drug 3. Receptor antagonists may allow one to determine the exact molecular site of action of the discriminable drug 4. Acquisition of drug discrimination may be blocked by antagonists |
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6-aminonicotinamide
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cleft palate teratogen at days 8-13. Teratogenicity affected by ambient temperature.
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When does CytP450 develop?
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Wk 6
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What do cycloheximide and anisomycin do?
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Inhibit protein synthesis.
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Antipsychotics
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raclopride(D2), clozapine (D4), reserpine, promethazine, chlorpromazine
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What is naltrexone used to treat?
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blocks opioid receptors, also nonspecific blockade
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