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23 Cards in this Set

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define: Epidemiology
a branch of medical science that deals with the incidence, distribution, and control of disease in a population.
Define: Incidence and Prevalence
Incidence: The number of new cases contracted in a population during a specific period of time.

Prevalence: Total number of people infected in a population during any given time
Define: Morbidity vs Mortality Rates
Morbidity= # of ppl affected in relation to the total number of ppl in a population.

Mortality: Number of deaths during a specific period in relation to the total population.
Define: Endemic Disease
present continually but the number of cases and severity remain too low to constitute a problem (what does graph look like vs epidemic? Slide 7 CH15)
Define: Epidemic and Pandemic
Also: 2 Examples of epidemics given
Epidemic= High number of cases and severe disease.

Examples are diphtheria in USSR after its split (1989-1997) and St, Louis encephalitis.
Pandemic- An epidemic that spreads worldwide
Sporadic Disease
Occurs in a random and unpredictable manner, involving several isolated cases that pose no great threat to the population as a whole.
Epidemiological Studies: Descriptive Studies
Concerned about disease spread and records:
1) Number of cases
2) Segments of population affected
3) Locations and time period of cases.

Additionally age, gender, race, marital, and economic status are recorded.
Common-Source Outbreaks and Propagated Epidemics
Common Source- all cases occur within a short time after exposure and then stop

Propagated Epidemics- New cases are continually seen

(Graph for both of these looks like)
John Snow
Essentially began the field of epidemiology through his study of cholera originating from a water pump on a street in London.
Analytic Studies of Epidemiology
Focus on cause and effect relationship.

1) Retrospective- past data (ex: Smoking and cancer)
2) Prospective- As epidemic spreads (ex: hantavirus oubreak in 1993 in US)
Experimental Studies
designs experiments to test a hypothesis. Polio vaccine was done in this was (placebo and no placebo group)
Reservoirs of Infection
1) Human- Carriers (harbor disease w/o any symptoms)
2 types: Chronic and Intermittent

2) Animal-Monkeys are most major. They carry malaria yellow fever etc

3) Nonliving-Soil and water. Ex: C. tetani, C. Botulinum, Salmonella
Zoonoses
Diseases that can be transmitted (under nat. conditions) to humans from other vertebrates.
Portals of Entry
Ear, eye, nose, mouth, mammary glands, urethra, vagina, anus, placenta, broken skin, seminal vesicles.
Modes of Transmission: Contact
1) Direct- ex: syphilis, staph, warts, most STD's
2) Indirect- Tetanus, common cold, enterovirus
3) Droplets- Common cold, influenza, measles, Q fever, pneumonia, whooping cough
Modes of Transmission: Vehicle
1) Waterborne- Cholera, shigelliosis, Camphylobacter

2) Airborne- Chicken Pox, tuberculosis

3) Foodborne- botulinum toxin
Modes of Transmission: Vector
1) Mechanical- on insect bodies
ex: E-coli, diarrhea, salmonella
2) Biological: Plaque, malaria, yellow fever etc
Herd Immunity
As the number of individuals who are immune to a disease increases, the likelihood that they will come into contact with the disease drops
CDC slide
States that measles has decreased by 55% in 1997
Nosocomial Infections (3 Types)
Acquired in a hospital or other medical facility:
1) Exogenous Infections (environment)
2) Endogenous Infections (opportunists)
Common caussative agents of nosocomial infections (4)
1) Escherichia Coli
2) Staphylococcus Aureus
3) Streptococcus
4) Pseudomonas/ Klebsiella (Tied)
Relative Frequencies of Sites of Nosocomial Infections
1) Urinary Tract
2) Surgical Wounds
3) Respiratory Tract
Bioterrorism Agents
1) Anthrax(1-5d)
2) Botulism(1-5d)
3)Plague (2-3d)
4) Smallpox
5)Tularemia (7-17d)
6) Ebola Virus (14d)
7) Marburg- Hemorrhagic Fever (8d)