Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Name the layers of the Glomrular filtration membrane.
|
1. Endothelium of a fenestrated capillary
2. Basement membrane 3.Membrane of bowman's capsule |
|
|
What is the membrane of bowman's capsule composed of?
|
wall of podocytes
|
|
|
What are the openings between the cells in the wall of podocytes?
|
filtration slits
|
|
|
Where does the fluid pass from the bloodstream to the renal tubule?
|
through filtration membrane
|
|
|
What things pass through the filtration membrane?
|
water, glucose, Na+, K+, Cl-
|
|
|
What happens to the large particles in the filtration membrane? What are they?
|
They get stuck and are ingulfed by podocytes.
They are cells & protiens |
|
|
What is the GFR (glomerular filtration rate)?
|
125ml/min
|
|
|
What are the factors that affect GFR?
|
-blood pressure
==>pressure up GFR up ==>pressure down GFR down -structural characteristic of filtration membrane ==> can tear ==> can clog |
|
|
What are the two controls that regulate glomerular filtration Rate?
|
1. intrinsic- acts locally w/in kidney
2. Extrinsic -uses neural & hormonal regulation |
|
|
What is myogenic mechanism?
|
when vascular smooth muscle resist changes to diameter
|
|
|
What are the two intrinsic controls for regulation of GFR
|
-Myogenic mechanism
-Tubuloglomerular feedback mechanism |
|
|
What does myogenic mechanism compensate for?
|
changes in systemic blood pressure
|
|
|
What do the tubuloglomerular feedback mechanism ?
|
-uses the macula densa cells
-use tubular osmolarity to adjust GFR |
|
|
What do the the Macula densa cells do when GFR is to high?
|
release vasoconstrictors(adenosine)
-which decreases GFR by limiting blood flow |
|
|
What do the the Macula densa cells do when GFR is to low?
|
NOT releasing adenosine we get dilation
|
|
|
What are the two extrinsic controls
|
-sympathetic controls
-Renin-angiotensin pathway |
|
|
What are GFR extrinsic controls most effective at ?
|
pressure extremes
-below 80 torr systolic -above 180 torr systolic |
|
|
During sympathetic input how is GFR effected and why?
|
GFR decreases
-during periods of stress blood is sent to vial organs & SHUNTED AWAY FROM KINDNEYS |
|
|
How does Rennin-angiotensin pathways affect GFR?
|
GFR increases due to Granular cells release of rennin.
acts as vasoconstrictor induce aldosterone & ADH release |
