Bio 103 Genetic Disorders

Front 1

T-F: Many human genetic disorders are inherited according to Mendel's laws

Back 1

True; the pattern of inheritance indicates whether the disorder is recessive or dominant

Front 2

T-F: Recessive disorders require the inheritance of only one recessive allele

Back 2

False; a recessive disorder requires the inheritance of two recessive alleles

Front 3

T-F: If a single allele for a dominant disorder is inherited, then the disorder will appear

Back 3

True; dominant disorders appear is a single dominant allele is inherited

Front 4

T-F: There are forms of inheritance that involve "degrees of dominance," multiple alleles and polygenes

Back 4

TRUE

Front 5

T-F: environmental factors cannot influence the expression of a gene

Back 5

FALSE

Front 6

T-F: In humans, the chromosome pairs 1-11 are considered autosomes

Back 6

False; pairs 1-22

Front 7

List the possible genotypes for someone with an autosomal dominant genetic disorder (A)

Back 7

AA and Aa

Front 8

List the possible genotypes for someone with an autosomal recessive genetic disorder (a)

Back 8

aa only

Front 9

Consider two patterns of inheritance for an autosomal genetic disorder. In pattern I, two unaffected parents have an affected child. In pattern II, two affected parents have an unaffected child. Which pattern is for an autosomal dominant genetic disorder, and which is for an autosomal recessive disorder?

Back 9

Pattern I is autosomal dominant; Pattern II is autosomal recessive.

Front 10

T-F: For autosomal recessive genetic disorders - most affected children have unaffected parents

Back 10

TRUE

Front 11

T-F: For autosomal recessive genetic disorders - heterozygotes (Aa) have an affected phenotype

Back 11

FALSE

Front 12

T-F: For autosomal recessive genetic disorders - two affected parents will always have affected children

Back 12

TRUE; if the disorder is autosomal dominant, then two affected parents can produce an unaffected child

Front 13

T-F: For autosomal recessive genetic disorders - affected individuals with homozygous unaffected mates will have unaffected children

Back 13

TRUE

Front 14

T-F: For autosomal recessive genetic disorders - close relatives who reproduce are more likely to have affected children

Back 14

TRUE

Front 15

T-F: For autosomal recessive genetic disorders - males and females are affected with equal frequency

Back 15

TRUE

Front 16

T-F: For autosomal dominant genetic disorders - affected children will usually have two unaffected parents

Back 16

FALSE

Front 17

T-F: For autosomal dominant genetic disorders - heterozygotes (Aa) are unaffected

Back 17

FALSE

Front 18

T-F: For autosomal dominant genetic disorders - two affected parents can produce an unaffected child

Back 18

True; if the disorder is autosomal recessive, then two affected parents will always have affected children

Front 19

T-F: For autosomal dominant genetic disorders - two unaffected parents can produce affected children

Back 19

False; if the disorder is autosomal dominant, then two unaffected parents will not have affected children

Front 20

T-F: For autosomal dominant genetic disorders - both males and females are affected with equal frequency

Back 20

TRUE

Front 21

Autosomal dominant or autosomal recessive disorder?: Tay-Sachs disease

Back 21

autosomal recessive

Front 22

Autosomal dominant or autosomal recessive disorder?: Cystic Fibrosis

Back 22

autosomal recessive

Front 23

Autosomal dominant or autosomal recessive disorder?: Phenylketonuria

Back 23

autosomal recessive

Front 24

Autosomal dominant or autosomal recessive disorder?: Sickle Cell Disease

Back 24

autosomal recessive

Front 25

Autosomal dominant or autosomal recessive disorder?: Neurofibromatosis

Back 25

autosomal dominant

Front 26

Autosomal dominant or autosomal recessive disorder?: Huntington disease

Back 26

autosomal dominant

Front 27

Autosomal dominant or autosomal recessive disorder?: achondroplasia

Back 27

autosomal dominant

Front 28

Autosomal dominant or autosomal recessive disorder?: von Recklinghausen disease

Back 28

autosomal dominant

Front 29

X-linked dominant or X-linked recessive genetic disorder?: Color blindness

Back 29

X-linked recessive

Front 30

X-linked dominant or X-linked recessive genetic disorder?: Muscular dystrophy

Back 30

X-linked recessive

Front 31

X-linked dominant or X-linked recessive genetic disorder?: Hemophilia

Back 31

X-linked recessive

Front 32

T-F: X-linked recessive disorders are more likely in females than males

Back 32

False; X-linked recessive disorders are more likely in males than females

Front 33

X-linked dominant or X-linked recessive genetic disorder?: Fragile X Syndrome

Back 33

Neither -- phenotypic expression varies with the number of CGG repeats at the "fragile site" on the X-chromosome; more than 230 repeats shows Fragile X symptoms, while less than 230 repeats generally do not show Fragile X symptoms

Front 34

Another name for Trisomy 21

Back 34

Down syndrome

Front 35

XO -- one X chromosome, and the "O" signifies the absence of a second sex chromosome. Name the syndrome

Back 35

Turner syndrome

Front 36

XXY

Back 36

Klinefelter syndrome

Front 37

XYY

Back 37

Jacobs syndrome

Front 38

Superfemales

Back 38

Poly-X females (three or more Xs and no Ys)

Front 39

Deletion or translocation syndrome?: Williams syndrome

Back 39

deletion

Front 40

Deletion or translocation syndrome?: Alagille syndrome

Back 40

translocation

Front 41

Deletion or translocation syndrome?: Cri du chat (cat's cry)

Back 41

deletion

Front 42

Deletion or translocation syndrome?: chronic myelogenous leukemia

Back 42

translocation

Front 43

Deletion or translocation syndrome?: Burkett lymphoma

Back 43

translocation

Front 44

The Philadelphia chromosome is associated with which translocation syndrome?

Back 44

chronic myelogenous leukemia