Big Book Derma

Front 1

PORPHYRIA CUTANEA TARDA is what kind of a disease

Back 1

Chronic blistering disease
Blistering and erosions on sun-exposed areas,
including hands and face.

Front 2

PORPHYRIA CUTANEA TARDA caused by wht defi

Back 2

uroporphyrinogen decarboxylase

Front 3

PORPHYRIA CUTANEA TARDA association with

Back 3

liver disease due to alcohol use,
viral hepatitis, or exposure to estrogen. Familial forms are less
common.

Front 4

ECTHYMA GANGRENOSUM

Back 4

Cutaneous manifestation of sepsis,

Front 5

ECTHYMA GANGRENOSUM due to

Back 5

due to Pseudomonas

Front 6

ECTHYMA GANGRENOSUM morphology

Back 6

Pustules with central hemorrhagic bullae that
develop into necrotic ulcers

Front 7

PYODERMA GANGRENOSUM seen in wht pts

Back 7

Seen in 5% of patients with ulcerative colitis.

Front 8

PYODERMA GANGRENOSUM morphology

Back 8

prog ulceration
well-defined margins.
purple base with surrounding red border

Front 9

PYODERMA GANGRENOSUM
Clinical presentation

Back 9

similar to cellulitis with erythema and pain.
do not respond to antibiotic therapy
and treated with steroid drugs.

Front 10

NECROBIOSIS LIPOIDICA ass with

Back 10

Uncommon disorder associated with diabetes
mellitus.

Front 11

NECROBIOSIS LIPOIDICA morphology

GROSS

Back 11

Oval-shaped, yellow-brown plaques on the anterior
surfaces of the lower legs.

Front 12

NECROBIOSIS LIPOIDICA morphology

micro

Back 12

Histiocytomas, PAS-positive areas of necrobiosis.

Front 13

Impetigo Infection with

Back 13

group A Streptococcus or Staphylococcus
aureus; due to toxin that cleaves desmoglein 1.

Front 14

Impetigo ass with

Back 14

honey colored crust

Front 15

Impetigo gross

Back 15

Erythematous macules forming pustules

mostly face and hand

Front 16

Impetigo Microscopic

Back 16

Neutrophils in stratum corneum; can form pustules.

Front 17

VERRUCAE VULGARIS occurs in

Back 17

children and adolescents

Front 18

VERRUCAE VULGARIS infected with

Back 18

human papillomavirus

Front 19

VERRUCAE VULGARIS micro

Back 19

Epidermal hyperplasia with koilocytic
changes.

Front 20

ERYTHEMA NODOSUM is

Back 20

acute form of panniculitis

Front 21

ERYTHEMA NODOSUM GROSS

Back 21

Poorly defined, tender, erythematous plaques. felt but not seen.
few weeks, plaques flatten
and become bruise-like.

Front 22

ERYTHEMA NODOSUM micro

Back 22

Early stages: Edema, fibrin, neutrophils in connective
tissue septae.

~ Later stages: Lymphocytes, macrophages, and multinucleated
giant cells in connective tissue septae

Front 23

ERYTHEMA NODOSUM arises in ass with

Back 23

-hemolytic streptococcal upper respiratory tract infections,
tuberculosis, sulfonamide therapy, oral contraceptive use, and
inflammatory bowel disease.

Front 24

ERYTHEMA NODOSUM is most common cutaneous lesion ass with

Back 24

sarcoidosis

Front 25

GRANULOMA ANNULARE most cases

Back 25

diagnosed in younger
than age 30 years; more common in females

Front 26

GRANULOMA ANNULARE most often affects

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dorsal surfaces of feet and hands and extensor surfaces of legs and arms

Front 27

GRANULOMA ANNULARE lesion begins as an

Back 27

annular ring of
small, firm, flesh-colored or red papules. The ring expands outward
with time, with involution and resolution of central
involvement.

Front 28

Causes of granuloma annulare

Back 28

Associated with a variety of
conditions, including tuberculosis, trauma, human immunodeficiency
virus (HIV) and HSV infections, and insect bites

Front 29

DERMATITIS HERPETIFORMIS affects wht gender more

Back 29

Affects males more frequently than females;
third and fourth decades of life.

Front 30

DERMATITIS HERPETIFORMIS resonds

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to gliadin-free diet.

Front 31

DERMATITIS HERPETIFORMIS gross

Back 31

Extremely pruritic plaques and vesicles.

Front 32

DERMATITIS HERPETIFORMIS areas aff

Back 32

Bilateral and symmetrical; affects extensor surfaces and buttocks.

Front 33

DERMATITIS HERPETIFORMIS MICRO

Back 33

In the early stages, clusters of neutrophils and fibrin at the tips of dermal papillae; by immunofluorescence,
these clusters at the tips of dermal papillae stain positive for
IgA; subepidermal blisters are formed.

Front 34

BULLOUS PEMPHIGOID happens in wht age

Back 34

older

Front 35

BULLOUS PEMPHIGOID antibodies against... produce

Back 35

hemidesmosomes; produces linear pattern at the basement mem on immunoflurescence

Front 36

BULLOUS PEMPHIGOID gross

Back 36

Tense, up to 2.0-cm bullae. bullae do not rupture as easily as emphigus; thus the Nikolsky sign is
negative.

Front 37

BULLOUS PEMPHIGOID aff area

Back 37

Areas affected: Inner thighs, flexor surface of forearms, axillae,
and groin; can involve oral mucosa (10–15% of
patients), but not as often as in pemphigus.

Front 38

BULLOUS PEMPHIGOID micro

Back 38

Microscopic: Subepidermal nonacantholytic bullae; basal
cell vacuolation; can have perivascular neutrophils, lymphocytes,
and eosinophils.

Front 39

Pemphigus Vulgaris Areas involved

Back 39

oral mucosa prominent
scalp
face n chest

Front 40

Pemphigus Vulgaris Antibody target

Back 40

desmoglein 3

Front 41

Pemphigus Vulgaris pattern on immunofluorescence

Back 41

net-like pattern

Front 42

Pemphigus Vulgaris Nikolsky sign

Back 42

positive

Front 43

Bullous Pemphigoid Areas involved

Back 43

extermities
axille
groin
oral mucosain 10-15%

Front 44

Bullous Pemphigoid Antibody target

Back 44

hemidesmosomes

Front 45

Bullous Pemphigoid pattern on immunoflu

Back 45

liner pattern at basement mem

Front 46

Bullous Pemphigoid Nikolsky sign

Back 46

neg

Front 47

Dermatitis Herpetiformis area involved

Back 47

extensor surfaces; buttocks

Front 48

Dermatitis Herpetiformis antibody target

Back 48

fliadin and reticulin

Front 49

Dermatitis Herpetiformis pattern on immu

Back 49

Iga pos clusters at tips of dermal papille

Front 50

PEMPHIGUS four forms?

Back 50

vulgaris,
vegetans, foliaceous, and erythematosus

Front 51

PEMPHIGUS VULGARIS cases

Back 51

about 80%

Front 52

PEMPHIGUS VULGARIS areas aff

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begin on the oral mucosa
and later involve skin of the scalp, face, chest, axillae, and groin

Front 53

PEMPHIGUS VULGARIS Pathogenesis

Back 53

IgG to desmoglein 3 (an intercellular cement
substance) produces a net-like pattern on immunofluorescence.

Front 54

Morphology of pemphigus vulgaris
gross

Back 54

Flaccid bullae, which readily rupture leaving superficial
erosions. Nikolsky sign is positive.

Front 55

Morphology of pemphigus vulgaris
micro

Back 55

Suprabasal bullae with intercellular deposits of
IgG and C3

Front 56

Pemphigus vegetans Areas affected:

Back 56

Areas affected: flexural areas.

Front 57

Pemphigus vegetans gross

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Wart-like plaques

Front 58

Pemphigus foliaceous AE

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Scalp, face, and chest

Front 59

Pemphigus foliaceous seen in wht ppl

Back 59

south americans

Front 60

Pemphigus foliaceous gross

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Superficial bullae.

Front 61

Pemphigus foliaceous

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Subcorneal bullae.

Front 62

Pemphigus erythematosus: Affects the

Back 62

malar area of the face.

Front 63

SEBORRHEIC DERMATITIS Pathogenesis

Back 63

Unknown; some cases may be due to Malassezia furfur

Front 64

Morphology of seborrheic dermatitis gross

Back 64

Moist or “greasy” macules and papules on an erythematous
base; has scaling and crusting.

Front 65

seborrheic dermatitis aff areas

Back 65

Areas with sebaceous glands such as the scalp, face, anterior chest, and intertriginous areas.

Front 66

seborrheic dermatitis microscopic

Back 66

Early stages: Spongiosis.
~ Later stages: Acanthosis.
~ Can have parakeratosis, neutrophils, and serum near the
hair follicles; lymphocytes and neutrophils are in a
perivascular distribution.

Front 67

forms of seborrheic dermatitis

Back 67

Dandruff in adults and cradle cap in infants are forms of seborrheic dermatitis

Front 68

PSORIASIS incidence

Back 68

1–2% of the population in the United States is affected

Front 69

PSORIASIS 2/3 of these patients have

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HLA-Cw 0602

Front 70

PSORIASIS rarely

Back 70

pustular

Front 71

PSORIASIS two forms are

Back 71

benign and generalized

Front 72

Benign pustular psoriasis:

Back 72

involves hands and feet

Front 73

Benign pustular psoriasis:

Back 73

Life threatening due to secondary
infections and electrolyte abnormalities

Front 74

Morphology of psoriasis gross

Back 74

Red plaque covered with silvery-white scales. Removal
of the scale causes petechial bleeding (Auspitz sign). Brown
discoloration (“oil spots”) and pitting of nails is classic

Front 75

psoriasis area aff

Back 75

Elbows, knees, scalp, and lumbosacral
region; may involve the nails

Front 76

psoriasis micro

Back 76

Acanthosis; elongated dermal papillae with
thinning of overlying epidermis and parakeratosis; neutrophils
clustered in parakeratosis (i.e., Munro microabscesses).

Front 77

psoriasis ass condition

Back 77

Psoriatic arthritis is one of the seronegative
spondyloarthropathies related to Reiter disease and ankylosing
spondylitis. It occurs in 5% of patients with psoriasis.
Patients are positive for HLA-B27. Psoriatic arthritis is characterized
by psoriasis, arthritis, and spondylosis.