Bhl Week 3: Hodgkin Lymphomas

Front 1

Hodgkin lymphomas are characterized by the presence of which distinctive cell?

Back 1

Reed-Sternberg cell

Front 2

How do Hodgkin lymphomas compare to NHLs based on pattern of spread?

Back 2

Hodgkin lymphomas spread in an orderly, contiguous fashion

NHLs spread in a disseminated, non-contiguous fashion

Front 3

How do Hodgkin lymphomas compare to NHLs based on nodal involvement?

Back 3

Hodgkin lymphomas tend to involve central or axial lymph nodes. Extranodal presentation RARE.

NHLs involve both central and peripheral nodes. Extranodal presentation not uncommon

Front 4

Which type of lymphoma is more likely to involve mesenteric nodes and Waldeyer's ring-- Hodgkin or Non-Hodgkin lymphomas?

Back 4

Non-hodgkin lymphomas

Front 5

Are hodgkin lymphomas more are less common than non-hodgkin lymphomas?

Back 5

Less common

Front 6

Describe the age distribution of hodgkin lymphomas.

Back 6

Bimodal age distribution in the U.S.
First peak -- 20s
Second peak-- 60s

Front 7

Describe the role of EBV in hodgkin lymphoma.

Back 7

EBV genome is present within malignant cells in ~50% of cases. It is shown to be clonal in all Reed-Sternberg cells from a single patient

Front 8

Are Hodgkin lymphomas primarily derived from B- or T-cells?

Back 8

B-cells

Front 9

List the 4 parts of the Rye classification of hodgkin lymphomas.

Back 9

1. Lymphocytic predominance
2. Nodular sclerosis
3. Mixed cellularity
4. Lymphocytic depletion

Front 10

Describe the WHO classifications of Hodgkin lymphomas.

Back 10

1. Nodular lymphocyte predominant HL
2. Classical Hodgkin lymphoma
- Nodular sclerosis HL
- Mixed cellularity HL
- Lymphocyte-rich classical HL
- Lymphocyte-depleted classical HL

Front 11

Which subtype of hodgkin lymphoma has a phenotype consistent with B-cell non-Hodgkin lymphoma?

Back 11

Nodular lymphocyte predominant HL

Front 12

Nodular lymphocyte predominant HL is more common in which individuals?

Back 12

Young males

Front 13

What is the most common subtype of HL?

Back 13

Nodular sclerosis Classical HL

Front 14

Is Nodular scleorosis classical HL more common in men or women?

Back 14

Men ~=~ Women

Front 15

Nodular sclerosis characteristically involves which lymph nodes?

Back 15

Lymph nodes ABOVE the diaphragm-- especially mediastinal lymph nodes

Front 16

What is the second most common subtype of HL?

Back 16

Mixed cellularity classical HL

Front 17

Nodular lymphocyte predominant HL and Nodular sclerosis HL both typically present at which stage?

Back 17

Stage II

Front 18

Mixed cellularity classical HL often presents at which stage?

Back 18

Advanced stage (III-IV)

Front 19

Does mixed cellularity classical HL tend to present in older or younger populations?

Back 19

Older populations

Front 20

Mixed cellularity classical HL tends to involve which nodes?

Back 20

Intra-abdominal lymph nodes

Front 21

Which HL subtype tends to have more frequent R-S cells?

Back 21

Mixed cellularity classical HL

(More frequent malignant cells; less benign cells)

Front 22

What type of cells are common in Mixed cellularity classical HL?

Back 22

Eosinophils and plasma cells

Front 23

Lymphocyte-rich classical HL usually occurs in what type of age group--younger or older individuals?

Back 23

Slightly older individuals (~50yo)

Front 24

All variants of hodgkin lymphoma are more commonly seen in men except one subtype. What is this subtype?

Back 24

Nodular sclerosis classical HL

Front 25

Lymphocyte-rich classical HL usually present at which stage?

Back 25

Stage I-II
(usually localized)

Front 26

What is the rarest variant of HL?

Back 26

Lymphocyte-depleted classical HL

Front 27

Which subtype tends to the be the most aggressive variant of HL?

Back 27

Lymphocyte-depleted classical HL

Front 28

What is the typical treatment for hodgkin lymphomas?

Back 28

Combination chemotherapy
(ABVD, MOPP/ABVD)

Adriamycin, bleomycin, vinblastine, dacarbazine)

Front 29

Are HIV-related hogkin lymphomas more or less common than HIV-related non-hodgkin lymphomas?

Back 29

Less common

*HIV-related lymphomas are aggressive

Front 30

Hodgkin lymphomas predominantly involve which lymph nodes?

Back 30

Central and axial lymph nodes
(Cervical, supraclavicular, mediastinal, axillary, periaortic)

Front 31

What is the general prognosis of Nodular sclerosis classical HL?

Back 31

Relatively favorable

Front 32

What system is used to stage HL?

What does it measure??

Back 32

Ann Arbor System
(same as with NHL)

*Measures anatomic spread of disease +/- symptoms