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34 Cards in this Set
- Front
- Back
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Penicillin G
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Gm+
inhibit cell wall synth: transpeptidase activate autolysins Probenecid prolongs half life |
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Procaine & Benzathine salts
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Repository forms of PCN G
longer plasma levels Inhibit cell wall synth |
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PCN V
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spectrum identical to PCN G
PO only Inhibit cell wall synth |
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Methicillin
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S. aureus S. epidermidis
penicillinase resistant Inhibit cell wall synth MRSA is resistant |
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Oxacillin
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S. aureus S. epidermidis
penicillinase resistant Inhibit cell wall synth |
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Dicloxacillin
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S. aureus S. epidermidis
penicillinase resistant Inhibit cell wall synth |
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Nafcillin
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S. aureus S. epidermidis
penicillinase resistant Inhibit cell wall sythn |
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Ampicillin
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Gm+ HELPSS kill Enterococci - H.influenzae, E.coli, Listeria, Proteus, Shigella, Salmonella, Enterococci
Amino or Extended Spectrum PCNs poor oral absorption = GI upset |
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Amoxicillin
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Gm+ HELPSS kill Enterococci - H.influenzae, E.coli, Listeria, Proteus, Shigella, Salmonella, Enterococci
PO only |
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Carbenicillin Indanyl
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Antipseudomonal PCN
prodrug PO tx for UTI |
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Ticarcillin
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Gm+, E.coli, H. influenzae, Salmonella, Shigella, some Proteus
indole + Proteus, Enterobacter, Pseudomonas |
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Clavulanic Acid
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irreversibly Beta lactamase Inhibitor
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Sulbactam
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irreversible Beta lactamase inhibitor
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Tazobactam
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irreversible Beta lactamase inhibitor
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Piperacillin
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Gm+ Gm -
Psuedomonas Klebsiella inhibit cell wall synth |
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Cephalexin
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Gm+ PEcK - E.coli, K. pneumoniae, P.mirabilis
PO only inhibiti cell wall sythn First Gen Cephalosporin |
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Cefazolin
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Gm+ PEcK; E.coli, K.pneumoniae, P.mirabilis
First Gen Cephalosporin inhibit cell wall sythn longer half life |
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Cefuroxime
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HEN PEcKS - H.influenzae, Enterobacter, Neisseria, Proteus, E.coli, Klebsiella
2nd Gen Cephalosporin More Gm- activity |
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Cefaclor
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HEN PEcKS - H.influenzae, Enterobacter, Neisseria, Proteus, E.coli, Kelbsiella, Serratia
2nd Gen cephalosporin More Gm- activity |
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Cefotetan
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HEN PEcKS; H.influenzae, Enterobacter, Neisseria, Proteus, E.coli, Klebsiella, B.fragilis
A Cephamycin 2nd Gen cephalosporin |
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Cefotaxime
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HEN PEcKS - H.influenzae, Enterobacter, Neisseria app, Proteus, E.coli, Klebsiella, Serratia
some CNS penetration 3rd Gen cephalosporin |
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Ceftazidime
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Enterobacteriaciae, P.aeruginosa, Serratia, N.gonnorrheae, S.aureus, S.pyogenes
Pseudomonas-most potent 3rd Gen cephalosporin |
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Ceftriaxone
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HEN PEcKS - H.influenzae, Enterobacter, Neisseria, Proteus, E.coli, Klebsiella, Serratia
Meningitis, Gonorrhea 3rd Gen cephalosporin |
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Cefepime
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4th Gen Cephalosporin
more resistance to B-lactamases |
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Ceftaroline
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5th Gen Cephalosporin
Only B-lactam activity against MRSA |
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Imipemem + Cilistatin
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Carbapenem
combined together to prevent inactivation of imipenem by the enzyme dehydropeptidase Gm(-) rods; Gm(+) cocci; Anaerobes Resistant to most PCNases & cephalosporinases Nosocomial infections |
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Meropenem
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similar to Imipenem
resistant to metabolism by dehydropeptidase |
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Ertapenem
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similar to Imipenem
resistant to metabolism by dehydropeptidase |
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Aztreonam
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aerobic Gm- = nosocomial
resistant to many B-lactamases No cross-sensitivity bt other B-lactams Monobactam |
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Vancomycin
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Glycopeptide: Gm+
inhibits transglycosylase-cell wall synthesis iv Redman/red neck syndrome Nephrotox Ototoxicity |
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Telavancin
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Lipoglycopeptides
inhibits cell wall synth Lipid tail causes depolarization of MB |
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Bacitracin
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inhibits dephosphorylation of P-55
inhibs cell wall synth topical only - extreme nephrotox |
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Cycloserine
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Inhibits alanine racemase
inhibs cell wall synth Tx TB |
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Fosfomycin
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inhibits early stage of cell wall synth
Tx UTI's |
