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18 Cards in this Set

  • Front
  • Back
Nadolol
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 1st
Penbutolol
MSA: 0
Lipid sol: High
ISA: +
Generation: 1st
Pindolol
MSA: +
Lipid sol: Low
ISA: +++
Generation: 1st
Propranolol
MSA: ++
Lipid sol: High
ISA: 0
Generation: 1st
Timolol
MSA: 0
Lipid sol: High
ISA: 0
Generation: 1st
Acebutolol
MSA: +
Lipid sol: Low
ISA: +
Generation: 2nd
Atenolol
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 2nd
Bisoprolol
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 2nd
Esmolol
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 2nd
Metoprolol
MSA: + (high doses)
Lipid sol: Moderate
ISA: 0
Generation: 2nd
Cartelol
MSA: 0
Lipid sol: Low
ISA: ++
Other actions: (up) NO; B2 agonist
Generation: 3rd
Carvedilol
MSA: ++
Lipid sol: Moderate
ISA: 0
Other actions: a1 blockade; antioxidant; antiproliferative
Generation: 3rd
Labetalol
MSA: +
Lipid sol: Low
ISA: +++
Other actions: a1 blockade; B2 agonist
Generation: 3rd
Betaxolol
MSA: +
Lipid sol: Moderate
ISA: 0
Other actions: vasodilation; Ca++ entry blocker
Generation: 3rd
Beta-Blockers: Clinical Indications
-Hypertension
-Glaucoma
-Migraine prophylaxis
-Hyperthyroidism
-Angina pectoris
-Acute MI
-Supraventricular arrhythmias
-Acute panic attacks
-Benign essential tremor
-Congestive heart failure
Beta-Blockers: MOA
-decrease CO (B1)
-decrease Ang II (B1)
-decrease NE release (B2)
-decrease SNS centrally
*Altered baro-reflex
Beta-Blockers: Adverse Effects
-Bronchoconstriction
-Cardio-depressive actions
-Disturbed glucose metabolism
-Impaired peripheral circulation
-Sudden withdrawal syndrome
-CNS effects (depression, nightmares, fatigue)
-Elevated triglycerides
Beta-Blockers: Drug Interactions
-Verapamil (CCB)
-Diltiazem (CCB)
-Clonidine (a2 blockers)