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18 Cards in this Set
- Front
- Back
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Nadolol
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MSA: 0
Lipid sol: Low ISA: 0 Generation: 1st |
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Penbutolol
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MSA: 0
Lipid sol: High ISA: + Generation: 1st |
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Pindolol
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MSA: +
Lipid sol: Low ISA: +++ Generation: 1st |
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Propranolol
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MSA: ++
Lipid sol: High ISA: 0 Generation: 1st |
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Timolol
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MSA: 0
Lipid sol: High ISA: 0 Generation: 1st |
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Acebutolol
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MSA: +
Lipid sol: Low ISA: + Generation: 2nd |
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Atenolol
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MSA: 0
Lipid sol: Low ISA: 0 Generation: 2nd |
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Bisoprolol
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MSA: 0
Lipid sol: Low ISA: 0 Generation: 2nd |
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Esmolol
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MSA: 0
Lipid sol: Low ISA: 0 Generation: 2nd |
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Metoprolol
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MSA: + (high doses)
Lipid sol: Moderate ISA: 0 Generation: 2nd |
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Cartelol
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MSA: 0
Lipid sol: Low ISA: ++ Other actions: (up) NO; B2 agonist Generation: 3rd |
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Carvedilol
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MSA: ++
Lipid sol: Moderate ISA: 0 Other actions: a1 blockade; antioxidant; antiproliferative Generation: 3rd |
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Labetalol
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MSA: +
Lipid sol: Low ISA: +++ Other actions: a1 blockade; B2 agonist Generation: 3rd |
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Betaxolol
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MSA: +
Lipid sol: Moderate ISA: 0 Other actions: vasodilation; Ca++ entry blocker Generation: 3rd |
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Beta-Blockers: Clinical Indications
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-Hypertension
-Glaucoma -Migraine prophylaxis -Hyperthyroidism -Angina pectoris -Acute MI -Supraventricular arrhythmias -Acute panic attacks -Benign essential tremor -Congestive heart failure |
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Beta-Blockers: MOA
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-decrease CO (B1)
-decrease Ang II (B1) -decrease NE release (B2) -decrease SNS centrally *Altered baro-reflex |
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Beta-Blockers: Adverse Effects
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-Bronchoconstriction
-Cardio-depressive actions -Disturbed glucose metabolism -Impaired peripheral circulation -Sudden withdrawal syndrome -CNS effects (depression, nightmares, fatigue) -Elevated triglycerides |
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Beta-Blockers: Drug Interactions
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-Verapamil (CCB)
-Diltiazem (CCB) -Clonidine (a2 blockers) |
