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9 Cards in this Set
- Front
- Back
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List the components of BPH
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*SMC inc A1 AR in prostate and blader neck
*Capsule blocks expansion out, so expansion goes in *Thick bladder wall, trabeculated and irritable *Bladder weakens *increased residual volume *SM cells have more collagen-->limit compliance *Inc pressure limits shortening which reduces contractile force and leaves a residual volume |
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So why is an icrease in a1 adrenoreceptors in SMCs in the prostate a problem?
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Their stimulation causes an increase in SMC tone which decreases LUTS
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What are LUTS?
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Lower urinary tract symptoms
Inc frequency of urination/nocturia Hesitation of initiation Dec force of urinary stream Post void dribbling Retention Urgency |
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What prevents radial expansion of the prostate?
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Fibrous capsule
Compresses the urethra instead |
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The bladder wall is thickened, trabeculated and irritable, what happens next?
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Hypersensitivity]increase in urinary frequency and LUTS
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Can the bladder stay strong forever?
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No.
It weakens which leads to a reduced contraction and increase in residual volume Possibly acute or chronic urinary retention |
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Why is SMC with more collagen in it a problem?
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They limit compliance and shortening of the cells. Which means contractile forces are reduced and pressure just builds and builds
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So to describe symptoms, give it a try
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Frequency because its never fully emptied so the reflex goes on and on
Dribbling due to occlusion Hesitation because of occlusion Force of stream = reduced contractile force |
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Why has the bladder become thickend?
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Because it has had to work against a harder pressure to pump out the urine as the urethra diameter has been compromised. As any good muscle, the harder it works the bigger it gets
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