Behavioral Science Ch. 5 (Lecture)

Front 1

Separates frontal from parietal lobe

Back 1

Central sulcus

Front 2

Location of primary motor cortex (gyrus)

Back 2

precentral gyrus

Front 3

Primary motor cortex is what BA?

Back 3

BA 4

Front 4

primary somatosensory cortex is in what gyrus

Back 4

postcentral gyrus

Front 5

primary somatosensory cortex in what BA?

Back 5

BA 3,1,2

Front 6

Primary auditory cortex located where?

Back 6

Transverse temporal gyrus of Heschel

Front 7

Primary auditory cortex is what BA?

Back 7

BA 41

Front 8

Hearing info from one ear is transmitted to what sides of brain?

Back 8

Bilaterally

Front 9

Primary visual cortex located where?

Back 9

banks of calcarine sulcus

Front 10

Primary visual cortex is what BA?

Back 10

BA 17

Front 11

What BA's are supplementary motor areas?

Back 11

BA 6, 8

Front 12

Aphasia caused by leson in posterior superior temporal gyrus of a dominant hemisphere.

Back 12

Wernicke's Aphasia

Front 13

Language comprehension is what area (name)? BA?

Back 13

Wernicke's Area
BA 22

Front 14

Term for speech dysfunction

Back 14

dysarthria

Front 15

term for language dysfunction

Back 15

aphasia

Front 16

Caused by lesion in the arcuate fasciculus

Back 16

Conduction aphasia

Front 17

Transmits language info from Wernike's to Broca's

Back 17

Arcuate Fasciculus

Front 18

Aphasia caused by lesion in the inferior frontal gyrus in dominant hemi.

Back 18

Broca's Aphasia

Front 19

Broca's BA?

Back 19

BA 44, 45

Front 20

Combination of all 3 aphasias is called?

Back 20

Global aphasia

Front 21

Pt with left hemineglect and anosognosia. Where is lesion?

Back 21

Right parietal cortex (stroke)

Front 22

Term for patient being unaware of a deficit

Back 22

Anisognosia

Front 23

Area of cortex that is "very important" in psych

Back 23

Prefrontal cortex

Front 24

Prefrontal cortex is what BA's?

Back 24

BA's 9, 10, 11

Front 25

Lesions here cause apathetic and lifeless behavior

Back 25

Dorsolateral convexity of prefrontal cortex

Front 26

Lesions here cause impulsive, disinhibited behavior and poor judgement

Back 26

Orbitofrontal (prefrontal cortex)

Front 27

Collection of structures, primary in temporal lobe, involved with learning, emotions, and memory.

Back 27

Limbic System

Front 28

Limbic system nucleus in the medial temporal lobe

Back 28

Amygdala

Front 29

Bilateral lesion of amygdala causes what disease?

Back 29

Kluver-Bucy Syndrome

Front 30

MCC of bilat. amygdala lesion?

Back 30

Herpes Simplex encephalitis (targets temporal lobe)

Front 31

15yo pt brought to office by parents w c/o:
overindulgence in sex
oral exploration.
inc appetite
listless personality
recent herpes simplex
Dx?

Back 31

Kluver-Bucy Syndrome

Front 32

Limbic structure important in neurobio of memory

Back 32

Hippocampus

Front 33

Median temporal lobe structure that resembles a seahorse

Back 33

Hippocampus

Front 34

name for limbic system connective circuit

Back 34

Papez Circuit

Front 35

Damage to papez circuit causes

Back 35

loss of memory

Front 36

Give Papez Circuit

Back 36

1. Cortex
2. Entohinal Cortex
3. Hippocampus
4. Mamillary bodies
5. Ant. Nucleus of Thalamus
6. Cingulate Gyrus
7. Hippocampus
8. Cortex (remembered)

Front 37

Part of papez circuit involved in alzheimer's

Back 37

Entohinal cortex

Front 38

Damage to neurons in Mammillary bodies due to what disease (name)? (Cause?)

Back 38

Wernicke's Encephalopathy (thiamine (B1) deficiency in alcoholics = neuron damage)

Front 39

Pt falls off bar stool. hx of EtOH. Nystagmus, abnl EOM (ophthalmoplegia), confusion, ataxia. Dx?

Back 39

Wernicke's Encephalopathy

Front 40

Tx for Wernicke's encephalopathy?

Back 40

IV Thiamine

Front 41

Survivors of Wernicke's Encephalopathy will have what sx? What is name of this condition?

Back 41

Dec memory. Wernicke-Korsakoff Syndrome

Front 42

Neurobiology of what NT is important in schizophrenia?

Back 42

Dopamine

Front 43

dopamine synthesized from what AA?

Back 43

Tyrosine

Front 44

Stimulus for release of Dopamine?

Back 44

AP opens Ca++ channel, Ca++ influx causes vesicle to move and fuse with membrane

Front 45

What type of postsynaptic dopamine receptors is blocked by schizophrenia drugs?

Back 45

D2 receptors

Front 46

Organized system of dopaminergic neurons starts where?

Back 46

Ventral Tegmental Area in the Midbrain

Front 47

VTA axons go where? What pathway?

Back 47

Limbic system. Mesolimbic pathway

Front 48

main pathway for neurobio of schizophrenia

Back 48

Mesolimbic pathway

Front 49

Dopaminergic pathway to cortex?

Back 49

mesocortical pathway

Front 50

Pathway that starts in substantia nigra and goes to basal ganglia to stratum. Important in Parkinson's

Back 50

Nigrastratum???

Front 51

Pathway to pituitary through infundibulum. Blocks effect of dopamine on PRL. Starts in Tuber (sp?)

Back 51

Tuberoinfundibular pathway

Front 52

Important in addiction psych.

Back 52

Nucleus Accumbens

Front 53

Main metabolite of dopamine

Back 53

Homovanillic acid (HVA)

Front 54

NT important in alzheimer's dz

Back 54

ACh

Front 55

main origin of ACh pathways

Back 55

Basal Nucleus of Meynert

Front 56

Alzheimer's drugs?
Mech?

Back 56

Aricept and Patch(???)
Inc [ACh] in synapse by dec breakdown of ACh

Front 57

Cause of MG?

Back 57

autoantibodies targetting nicotinic receptor at neuromuscular junction or CNS

Front 58

NT important in mood disorders and anxiety

Back 58

NE

Front 59

Organ that converts NE to Epi

Back 59

Adrenal medulla

Front 60

disease that can't convert NE to epi due to lack of enzyme

Back 60

Pheochromocytoma

Front 61

NE action is terminated by what mechanism

Back 61

reuptake

Front 62

Drugs that block NE reuptake

Back 62

TCA's
Cocaine

Front 63

Enzyme found in outer mitochondrial membrane

Back 63

MAO

Front 64

Effect of MAO on NT's?

Back 64

MAO degrades NT's (NE, Epi, Dopamine)

Front 65

MAO inhibitors used to tx?

Back 65

Parkinson's, etc ???

Front 66

Main origin of NE fibers?

Back 66

Locus Ceruleus (midbrain)

Front 67

NT for depression, OCD

Back 67

Serotonin (5-HT)

Front 68

Medications for depression, OCD. Block reuptake of 5HT

Back 68

SSRI's (prozac, zoloft, etc)

Front 69

Main nuclei for Serotonin

Back 69

Raphe' Nuclei

Front 70

Main inhibitory NT

Back 70

GABA

Front 71

Main excitatory NT

Back 71

Glutamate

Front 72

Tx for anxiety, seizures, sedation of ventilated pt's. Interacts with GABA receptor

Back 72

Benzodiazapines (Diazepam, Valium)

Front 73

GABA Sleeping Pill

Back 73

Zolpidem

Front 74

GABA drugs for seizures...

Back 74

Barbituates

Front 75

Biosynthesis of glutamate occurs in what cells?

Back 75

Glutamate

Front 76

Main glutamate receptor type?

Back 76

NMDA

Front 77

NMDA blockers used in tx of what diseases?

Back 77

Alzheimer's, substance abuse

Front 78

Sedative NMDA Blocker

Back 78

Ketamine

Front 79

major psychiatric diagnosis requires...

Back 79

significant impairment in functioning

Front 80

Always rule out...

Back 80

drug abuse

Front 81

criteria for hospitalization

Back 81

Any one:
Danger to self
Danger to others
Unable to provide food, clothing, shelter

Front 82

What are indicators of an unfavorable prognosis?

Back 82

Long onset of sx
Poor insight
Low premorbid function

Front 83

Which main disease in psych has main genetic component?

#2?

Back 83

Bipolar Depression (manic depressive)

#2: Alcoholsim